A0A0P9HLP0 · A0A0P9HLP0_9BACL
- ProteinCobyric acid synthase
- GenecobQ
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids920 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.
Catalytic activity
- O-phospho-L-threonine + H+ = (R)-1-aminopropan-2-yl phosphate + CO2
Pathway
Cofactor biosynthesis; adenosylcobalamin biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 739 | Nucleophile | |||
Active site | 851 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ABC-type vitamin B12 transporter activity | |
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | threonine-phosphate decarboxylase activity | |
Biological Process | cobalamin biosynthetic process | |
Biological Process | glutamine metabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCobyric acid synthase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus
Accessions
- Primary accessionA0A0P9HLP0
Proteomes
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 25-348 | Aminotransferase class I/classII large | |||
Compositional bias | 369-385 | Basic and acidic residues | |||
Region | 369-391 | Disordered | |||
Domain | 403-628 | CobQ/CobB/MinD/ParA nucleotide binding | |||
Domain | 660-858 | CobB/CobQ-like glutamine amidotransferase | |||
Sequence similarities
Belongs to the CobB/CobQ family. CobQ subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length920
- Mass (Da)101,405
- Last updated2016-01-20 v1
- ChecksumF8B5FB2C1BE9B67C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 369-385 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JTHN01000178 EMBL· GenBank· DDBJ | KPV56854.1 EMBL· GenBank· DDBJ | Genomic DNA |