A0A0P9HLP0 · A0A0P9HLP0_9BACL

  • Protein
    Cobyric acid synthase
  • Gene
    cobQ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site739Nucleophile
Active site851

GO annotations

AspectTerm
Molecular FunctionABC-type vitamin B12 transporter activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionthreonine-phosphate decarboxylase activity
Biological Processcobalamin biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cobyric acid synthase

Gene names

    • Name
      cobQ
    • ORF names
      QJ48_25285

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • A3
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus

Accessions

  • Primary accession
    A0A0P9HLP0

Proteomes

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain25-348Aminotransferase class I/classII large
Compositional bias369-385Basic and acidic residues
Region369-391Disordered
Domain403-628CobQ/CobB/MinD/ParA nucleotide binding
Domain660-858CobB/CobQ-like glutamine amidotransferase

Sequence similarities

Belongs to the CobB/CobQ family. CobQ subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    920
  • Mass (Da)
    101,405
  • Last updated
    2016-01-20 v1
  • Checksum
    F8B5FB2C1BE9B67C
MLERYGHGGDLWTAAEAFGKPRERFVDFSSNMNPLGPPKAVGRILAEQWQEVVHYPDPAVRELTGKLAAKHGVPVECVLVGNGAAELIDLAVRVRRPGVTGLVRPSFAEYEEAVEKIGGRIVDIPLDEANGFALRLADVQAAADRCDLLFLGHPNNPTGLLLPDDVVQALAEGEIPAIIDEAFLDFCPREEELTLARAAAQSPHLTVIRSMTKFYSIPGLRLGYVVAHPEQIREMKRLQVPWSVNALSQWIGSAVLEEREFVRRTLEWVKEEKDRLRAGLQSLGLTVYESDVNFVLFSLRPLGLDVRELQAAMGRRGILIRDASLFPGLDETYCRVAVKLREQNEALLDGLRQSIADLLEARERATAGEEAAAARRAEGSRSGDPFSSDEADSASLKLAPTFMLQGTASDVGKSLLTTALCRILLQDGLRVAPFKSQNMSLNSYVTPDGKEIGRAQGMQADACRIPATTDMNPILLKPKKDMVSQVVVHGKPYRDLDARTYREKYLPEAEAVVKEALARLRQAYDAVVIEGAGSPAEVNLKDRDIVNMRLAGWADAPVLLVADIDRGGVFASLVGTLDILSPEERGRVKGFIINKFRGDVTLLTPGIEWLEKRTGKPVLGVIPYLPQLGLEDEDSASLERKLAEGALGRIDTALSEDMLDIAVIRLPRLSNFTDIDPLEYERDVRLRFVDSAETFGSPDAVIVPGSKNTVDDLLYLRDCGLDRKLLDFAKSGGWVTGICAGYQMLGEKLLDPNAVESDQPVLDGLGLFPTQTVFAAEKRTVRAAGTTRLYADPEQAFEIQGYEIHMGVTSFLRPVDHPFELSHPDTGSAESGSSPDGAVCADGRLWGTYVHGILHNDDFRRAWLNRIRAAKGLEPLPAELRFQERREAAFDRLAAHVREHLDMERLYEMIGWNKGREGFQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias369-385Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JTHN01000178
EMBL· GenBank· DDBJ
KPV56854.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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