A0A0P8YHE3 · A0A0P8YHE3_DROAN

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcell cortex
Cellular Componentcell surface
Cellular Componentciliary rootlet
Cellular Componentdendritic shaft
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentgrowth cone
Cellular Componentlysosomal membrane
Cellular Componentmembrane raft
Cellular Componentmitochondrial inner membrane
Cellular Componentneuromuscular junction
Cellular Componentneuronal cell body
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular ComponentZ disc
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Biological Processamyloid precursor protein catabolic process
Biological Processamyloid-beta metabolic process
Biological Processcalcium ion transport
Biological Processmembrane protein ectodomain proteolysis
Biological Processnegative regulation of apoptotic process
Biological ProcessNotch receptor processing
Biological ProcessNotch signaling pathway
Biological Processprotein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin
  • EC number

Gene names

    • Name
      Dana\GF10339
    • Synonyms
      dana_GLEANR_10296
    • ORF names
      GF10339

Organism names

  • Taxonomic identifier
  • Strain
    • Tucson 14024-0371.13
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    A0A0P8YHE3

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane106-130Helical
Transmembrane150-175Helical
Transmembrane182-203Helical
Transmembrane215-234Helical
Transmembrane246-262Helical
Transmembrane268-284Helical
Transmembrane448-469Helical
Transmembrane475-494Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-92Disordered
Compositional bias40-56Polar residues
Region326-358Disordered
Compositional bias388-412Polar residues
Region388-418Disordered

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    508
  • Mass (Da)
    55,612
  • Last updated
    2016-01-20 v1
  • Checksum
    EE0D776FF4B24AC0
MAAHVQASSLPPSASAEGAGIVDGSVNGETERLERPPKRQNQRNNYGSNNQDQPDAAILAVPSVVVRDSGGSRPSRLSGGGGGGPPTNETEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYSSTDVYLLYTPFHELSPEPSVKLWNALANSLILMSVVVVMTILLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMAIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVIYTYMGTHYTPQQSQATASSSPSSSNSTTTTRATQNSLASPEATVASGSRSAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQSHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMENLSAKQVFI

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0P9C3T9A0A0P9C3T9_DROANDana\GF10339545
B3M997B3M997_DROANDana\GF10339531

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias40-56Polar residues
Compositional bias388-412Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH902618
EMBL· GenBank· DDBJ
KPU78360.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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