A0A0P7W950 · A0A0P7W950_SCLFO

Function

function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentconnexin complex
Molecular Functiongap junction channel activity
Biological Processcell-cell signaling
Biological Processgap junction-mediated intercellular transport

Names & Taxonomy

Protein names

  • Recommended name
    Gap junction protein

Gene names

    • ORF names
      Z043_122662

Organism names

Accessions

  • Primary accession
    A0A0P7W950

Proteomes

Subcellular Location

Cell junction, gap junction
Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane53-72Helical
Transmembrane130-154Helical
Transmembrane187-211Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_500614431522-366Gap junction protein

Interaction

Subunit

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain18-51Connexin N-terminal
Domain143-209Gap junction protein cysteine-rich
Region300-366Disordered
Compositional bias316-339Acidic residues
Compositional bias344-366Polar residues

Sequence similarities

Belongs to the connexin family. Alpha-type (group II) subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    366
  • Mass (Da)
    41,643
  • Last updated
    2016-01-20 v1
  • Checksum
    0792A2437395AB55
MTVLFIFRILILGTAAEFVWGDEQSDFVCNTKQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLVYVGHAVHHVHMEEKRKEREEAEMNRQQEMGEEQLPLAPDQGSVRTAKETSTKGSKKFRLEGTLLRTYVCHIIFKTLFEVGFVVGQYYLYGFHILPLYKCGRWPCPNVVDCFVSRPTEKTVFIIFMVAVAFVSLFLNFVEICYLGMKKIRLSFRKPPQPQGAALAPERNIPSIAVFSIQKAKGYKLLGDDKRASHLFPLTEVGMEAGRLPAAFEPLKEKVMEPVPLEESKVYNETLPSYVLTTEPEKKVPLEEEEQEEDQEEQEEPSAEGEMEATETTEDMRPLSSLSKASSRARSDDLTV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias316-339Acidic residues
Compositional bias344-366Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JARO02012171
EMBL· GenBank· DDBJ
KPP59418.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help