A0A0P7GB31 · A0A0P7GB31_9EURY

  • Protein
    Shikimate dehydrogenase (NADP(+))
  • Gene
    aroE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site14-16shikimate (UniProtKB | ChEBI)
Binding site61shikimate (UniProtKB | ChEBI)
Active site65Proton acceptor
Binding site85shikimate (UniProtKB | ChEBI)
Binding site100shikimate (UniProtKB | ChEBI)
Binding site124-128NADP+ (UniProtKB | ChEBI)
Binding site147-152NADP+ (UniProtKB | ChEBI)
Binding site213NADP+ (UniProtKB | ChEBI)
Binding site215shikimate (UniProtKB | ChEBI)
Binding site236NADP+ (UniProtKB | ChEBI)
Binding site243shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      SY89_01476

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CDK2
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae

Accessions

  • Primary accession
    A0A0P7GB31

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-87Shikimate dehydrogenase substrate binding N-terminal
Domain114-188Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Domain236-266SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    269
  • Mass (Da)
    27,980
  • Last updated
    2016-01-20 v1
  • Checksum
    3E3038ED593BD949
MDVYGLIGRPVEHSLSPPMHEAAYEARSLDARYVTLEPDPDRIEEAIDGADALGVAGLNVTVPFKQDVLPSVDPTPTAAAVGAVNTISFDGGTPEGHNTDTEGVTRALEHHDVAIEGQSAVVVGAGGAGRAATYALADAGAETFVANRTVERAAELAEEFADLGVESGGLDALADWLPQADLLVNATSVGMDDPDSSPVPAELLHGDLAVLDAVYSPLRTKLLRDAADVGATTVDGAWMLLYQGVAAFERWTGVDAPVAAMDRALRDRL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LGUC01000001
EMBL· GenBank· DDBJ
KPN30738.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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