A0A0P7FTQ5 · A0A0P7FTQ5_9EURY

  • Protein
    Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site105Fe cation (UniProtKB | ChEBI)
Binding site109Fe cation (UniProtKB | ChEBI)
Binding site126-130L-threonylcarbamoyladenylate (UniProtKB | ChEBI)
Binding site158L-threonylcarbamoyladenylate (UniProtKB | ChEBI)
Binding site171L-threonylcarbamoyladenylate (UniProtKB | ChEBI)
Binding site175L-threonylcarbamoyladenylate (UniProtKB | ChEBI)
Binding site271L-threonylcarbamoyladenylate (UniProtKB | ChEBI)
Binding site299Fe cation (UniProtKB | ChEBI)
Binding site362-370ATP (UniProtKB | ChEBI)
Binding site379ATP (UniProtKB | ChEBI)
Active site468Proton acceptor; for kinase activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular ComponentEKC/KEOPS complex
Molecular Function3-phosphoinositide-dependent protein kinase activity
Molecular FunctionAMP-activated protein kinase activity
Molecular FunctionATP binding
Molecular FunctionDNA-dependent protein kinase activity
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionhistone H2AS121 kinase activity
Molecular Functionhistone H2AT120 kinase activity
Molecular Functionhistone H2AXS139 kinase activity
Molecular Functionhistone H2BS14 kinase activity
Molecular Functionhistone H2BS36 kinase activity
Molecular Functionhistone H3S10 kinase activity
Molecular Functionhistone H3S28 kinase activity
Molecular Functionhistone H3S57 kinase activity
Molecular Functionhistone H3T11 kinase activity
Molecular Functionhistone H3T3 kinase activity
Molecular Functionhistone H3T45 kinase activity
Molecular Functionhistone H3T6 kinase activity
Molecular Functionhistone H4S1 kinase activity
Molecular Functioniron ion binding
Molecular Functionmetalloendopeptidase activity
Molecular FunctionN(6)-L-threonylcarbamoyladenine synthase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine/tyrosine kinase activity
Molecular FunctionRho-dependent protein serine/threonine kinase activity
Molecular Functionribosomal protein S6 kinase activity
Molecular Functionzinc ion binding
Biological ProcesstRNA threonylcarbamoyladenosine modification

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein

Including 2 domains:

  • Recommended name
    tRNA N6-adenosine threonylcarbamoyltransferase
  • EC number
  • Alternative names
    • tRNA threonylcarbamoyladenosine biosynthesis protein Kae1
    • t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1
  • Recommended name
    Serine/threonine-protein kinase Bud32
  • EC number

Gene names

    • ORF names
      SY89_00874

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CDK2
  • Taxonomic lineage
    Archaea > Methanobacteriati > Methanobacteriota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae

Accessions

  • Primary accession
    A0A0P7FTQ5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-338Kae1
Domain26-305Gcp-like

Sequence similarities

In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
In the N-terminal section; belongs to the KAE1 / TsaD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    548
  • Mass (Da)
    58,256
  • Last updated
    2016-01-20 v1
  • MD5 Checksum
    F58F4A00EF0E2D52D19FB3BB760588B1
MRVLGVEGTAWCASAAVHDTETDETFIESDAYEPDSGGIHPREAAEHMGDAIPRVIETALQRADGEIDAVAFSKGPGLGPCLRVAGTAARALAGTLDVPLVGVNHMVAHLEIGRHESGFDSPVCLNASGANAHLLGFHDGRYRVLGETMDTGVGNAIDKFTRHLGWSHPGGPKVEEAAKGGEYVDLPYVVKGMDFSFSGLMSAAKDAVGDVPASEASGGQSEHRSDDGEAVENVCFSLQEHVFAMLTEVSERALSLTGSDELVLGGGVGQNARLREMLAEMCEQRGAEFYAPEPRFLRDNAGMIAVLGAKMAAAGDTIEIADSAIDPDFRPDEVPVTWRDNESVAVGHGVTDGTSMSGLSDPRRGAEAVVDVQDGVIVKRRLPKGYRHPALDATLRRDRTVLEARLLSEARKAGVPTPLVHDVDVPEATLRLQHVGDSDLADALTAEHARELGGHLARLHDRGLVHGDPTTKNVRVGDRLFLVDFGLGYHSGHPEDHAMDLHVFEGSVAGTATDSAAICRAFEDGYAAVGDDVVLERLAEIRGRGRYQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LGUC01000001
EMBL· GenBank· DDBJ
KPN30151.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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