A0A0P0WC75 · A0A0P0WC75_ORYSJ

Function

function

Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc2Man9GlcNAc2-PP-Dol to produce Glc3Man9GlcNAc2-PP-Dol.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functiondolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity
Biological Processdolichol-linked oligosaccharide biosynthetic process
Biological Processleaf development
Biological Processresponse to salt stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
  • EC number

Gene names

    • Ordered locus names
      Os04g0503700

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    A0A0P0WC75

Proteomes

Genome annotation databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane50-69Helical
Transmembrane89-106Helical
Transmembrane118-136Helical
Transmembrane142-170Helical
Transmembrane269-289Helical
Transmembrane309-326Helical
Transmembrane347-370Helical
Transmembrane390-411Helical
Transmembrane418-441Helical
Transmembrane461-481Helical

Keywords

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region20-39Disordered
Compositional bias23-39Basic and acidic residues
Region211-231Disordered

Sequence similarities

Belongs to the ALG10 glucosyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    497
  • Mass (Da)
    56,520
  • Last updated
    2020-02-26 v1
  • Checksum
    C76A29E8A9ACAD09
ALCSRGARGWIWSGVSQRSGEEPVRVGDGEADRRRGSGRMGDPMITTPPGLYYISLAYVASLFPGAWVTRIAEAFDALCTTALLRSTNVIMAMICGVLVHDLLLCIRPKIGKRKATAFAILVALYPIHWFFTFLYYTDVASLAAVLAMYLFCLKKQFWVSAAFGAFSILLRQTNVIWMIFFAANGAIAHAQYLYVKDNVCYENSELTDKSNKEASHMDNKTTAPGLRRRRNNNPINKREVVSESNIMYSSFTEEIWDAIFKLWNSKCEVLIAFIPFAMVLLVFVAFIVWNGGIVLGAKEAHVVSPHFAQFLYFGLVSAAALLPWHFTPTRASDLFHWCRKNKTYSSFAILVALGLSLVAVHLFSIAHPYLLADNRHYTFYIWRKVIQVHWMMKYILTPVYVYSWFSIVNILGKSQTRLWVLSFVLSVALALIPAPLVEFRYYTIPLVILVLHSPVISNVKLLALGFLYAAVDFFTLAMFLFRPFQWQHEPGTQRFIW

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias23-39Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP008210
EMBL· GenBank· DDBJ
BAF15156.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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