A0A0P0V1R2 · A0A0P0V1R2_ORYSJ

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentgamma-secretase complex
Cellular ComponentGolgi membrane
Cellular ComponentGolgi-associated vesicle
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Molecular Functionendopeptidase activity
Biological Processmembrane protein ectodomain proteolysis
Biological ProcessNotch signaling pathway
Biological Processprotein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin
  • EC number

Gene names

    • ORF names
      OSNPB_010276400
    • Ordered locus names
      Os01g0276400

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    A0A0P0V1R2

Proteomes

Genome annotation databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Golgi apparatus membrane
; Multi-pass membrane protein

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region212-280Disordered
Compositional bias225-239Basic and acidic residues
Compositional bias265-280Polar residues
Region300-319Disordered

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    416
  • Mass (Da)
    44,306
  • Last updated
    2016-01-20 v1
  • Checksum
    C960B9D968D11B5D
AAAAQPPPPVTAATLVYLESPTDTPGQKLVGALLDAAVFVALVAVVTFVLVALYYYRCTGFLKNYMRFSAFFVLFSMGGAIAAAVLRRLGAPLDAATALVLLFNASAVGVLSVFASAVPIVVRQGYMVALAVIVAAWLSRLPEWTTWVMLIALALYDLVAVLAPRGPLRMLVELASSRDDELPALVYESRPTVGPASGSSSYASAMGSVEMQPVADPGRSGGNQYDRVEQEDDSSRAVVEMRDVGGSRSSIRERNLEREAPMAVSVSGHSSNQGGSSQHAVIQIEQHEEGETVPLVSAASANNAAPNEEHRENSSSDSGMEFEMFESTRGIKLGLGDFIFYSVLVGRAAMYDLMTVYACYLAIIAGLGCTLILLSICKHALPALPISILLGVTFYFLTRLLMEPFVVGSSTNLVMF

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias225-239Basic and acidic residues
Compositional bias265-280Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP014957
EMBL· GenBank· DDBJ
BAS71550.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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