A0A0N9Y545 · A0A0N9Y545_MYCFO

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from 2-oxoglutarate (transferase route): step 1/2.
Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.

GO annotations

AspectTerm
Molecular Function2-hydroxy-3-oxoadipate synthase activity
Molecular Function2-oxoglutarate decarboxylase activity
Molecular Functiondihydrolipoyllysine-residue succinyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionoxoglutarate dehydrogenase (succinyl-transferring) activity
Molecular Functionthiamine pyrophosphate binding
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional 2-oxoglutarate metabolism enzyme
  • EC number
  • Alternative names
    • 2-hydroxy-3-oxoadipate synthase
    • 2-oxoglutarate carboxy-lyase
    • 2-oxoglutarate decarboxylase
    • Alpha-ketoglutarate decarboxylase
    • Alpha-ketoglutarate-glyoxylate carboligase

Gene names

    • ORF names
      XA26_44680

Organism names

Accessions

  • Primary accession
    A0A0N9Y545

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, domain.

TypeIDPosition(s)Description
Region26-116Disordered
Compositional bias60-78Pro residues
Coiled coil800-827
Domain890-1089Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,241
  • Mass (Da)
    136,437
  • Last updated
    2016-01-20 v1
  • Checksum
    760283075582D521
MSAVSSSPSPFGQNEWLVEEMYRKFREDPSSVDPSWHEFLVDYSPEPTTDNTVANGQPAAPVAPPTPAPAPPAAPAAAPAQAAPAKAAPAKAAPAKPAPAKAAKSGPSPAEDDETQVLRGAAAAVVKNMNASLEVPTATSVRAIPAKLMIDNRVVINNHLKRTRGGKVSFTHLLGYAIVQAVKKFPNMNRYFAEVNGKPAAVTPAHTNLGLAIDLPGKDGNRSLVVAAIKRCETMHFGQFIAAYEDIVRRARDGKLTAEDFSGVTISLTNPGTIGTVHSVPRLMQGQGAIIGAGAMEYPAEFQGASEERIAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHQLLLDDEFFDEIFRELGIPYEPVRWRTDNPDSIADKNARVIELIAAYRNRGHLMADIDPLRLDNTRFRSHPDLDVNTHGLTLWDLDREFKVDGFSGKQYMKLRDVLSVLRDAYCRHIGVEYTHILEPEQQKWLQERIEIKHDKPTVAEQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAETVIPMMDAAIDQAAEHGLAEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGASGNYIQMFGDNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLDASKDADVSGEYPVVPLMLHGDAAFAGQGVVAETLNLALLDGYTTGGTVHIVVNNQIGFTTAPTDSRSSEYCTDVAKMIGAPIFHVNGDDPEACAWVARLAVDFRQKFKKDVVIDMLCYRRRGHNEGDDPSMTQPYMYDVIDTKRGSRKAYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKHAAEPSESVEADQQIPQRLATAVDKSLLARIGDAHLALPEGFTVHPRVKPVLEKRREMAYEGKIDWAFAELLALGTLISEGKLVRLSGQDTQRGTFTQRHAVIVDRKTGEEFTPLQLLATNTDGTPTGGKFLVYNSALSEYAAVGFEYGYSVGNPDAMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTIAVPSTPANYFHLLRRHGLDGIQRPLIVFTPKSMLRNKAAVSDIRDFTEQKFRSVLEESAYTDGEGDRSKVTRLLLCSGKIYYDLAARKAKDNRDDVAIVRLEQLAPLPRRRLAETLDRYPNVTEKFWVQEEPANQGAWPSLGLTLPEVLPEYFSPITRISRRAMSAPSSGSSKVHAVEQQEIIDLAFG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias60-78Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011269
EMBL· GenBank· DDBJ
ALI28268.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp