A0A0N9Y545 · A0A0N9Y545_MYCFO
- ProteinMultifunctional 2-oxoglutarate metabolism enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1241 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- 2-oxoglutarate + H+ + N6-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] = CO2 + N6-[(R)-S8-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]
Cofactor
Protein has several cofactor binding sites:
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from 2-oxoglutarate (transferase route): step 1/2.
Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-hydroxy-3-oxoadipate synthase activity | |
Molecular Function | 2-oxoglutarate decarboxylase activity | |
Molecular Function | dihydrolipoyllysine-residue succinyltransferase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | oxoglutarate dehydrogenase (succinyl-transferring) activity | |
Molecular Function | thiamine pyrophosphate binding | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional 2-oxoglutarate metabolism enzyme
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA0A0N9Y545
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 26-116 | Disordered | ||||
Sequence: REDPSSVDPSWHEFLVDYSPEPTTDNTVANGQPAAPVAPPTPAPAPPAAPAAAPAQAAPAKAAPAKAAPAKPAPAKAAKSGPSPAEDDETQ | ||||||
Compositional bias | 60-78 | Pro residues | ||||
Sequence: APVAPPTPAPAPPAAPAAA | ||||||
Coiled coil | 800-827 | |||||
Sequence: MKEAEDALRDYQGQLERVFNEVRELEKH | ||||||
Domain | 890-1089 | Transketolase-like pyrimidine-binding | ||||
Sequence: IDWAFAELLALGTLISEGKLVRLSGQDTQRGTFTQRHAVIVDRKTGEEFTPLQLLATNTDGTPTGGKFLVYNSALSEYAAVGFEYGYSVGNPDAMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTIAVPSTPANYFHLLRRHGLDGIQRPLIVFTPKSMLRN |
Sequence similarities
Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,241
- Mass (Da)136,437
- Last updated2016-01-20 v1
- Checksum760283075582D521
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 60-78 | Pro residues | ||||
Sequence: APVAPPTPAPAPPAAPAAA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP011269 EMBL· GenBank· DDBJ | ALI28268.1 EMBL· GenBank· DDBJ | Genomic DNA |