Essential maintenance is planned to begin on Tue Jan 28 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ during this time.

A0A0N9VXW2 · A0A0N9VXW2_PSEFL

  • Protein
    Ribosomal RNA large subunit methyltransferase K/L
  • Gene
    rlmL
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Function23S rRNA (guanine(2445)-N(2))-methyltransferase activity
Molecular FunctionRNA binding
Molecular FunctionrRNA (guanine-N7-)-methyltransferase activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ribosomal RNA large subunit methyltransferase K/L

Including 2 domains:

  • Recommended name
    23S rRNA m2G2445 methyltransferase
  • EC number
  • Alternative names
    • rRNA (guanine-N(2)-)-methyltransferase RlmL
  • Recommended name
    23S rRNA m7G2069 methyltransferase
  • EC number
  • Alternative names
    • rRNA (guanine-N(7)-)-methyltransferase RlmK

Gene names

    • Name
      rlmL
    • ORF names
      AO356_02605

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FW300-N2C3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A0N9VXW2

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain46-157THUMP
Compositional bias395-409Basic and acidic residues
Region395-436Disordered

Sequence similarities

Belongs to the methyltransferase superfamily. RlmKL family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    756
  • Mass (Da)
    85,064
  • Last updated
    2016-01-20 v1
  • MD5 Checksum
    CABB043518D432AB881421287126153D
MSDRFELFLTCPKGLEGLLIEEAVGLGLEEAREHTSAVRGMADMETAYRLCLWSRLANRVLLVLKRFPMKDAEDLYHGVLDVDWQDHMLADGTLAVEFSGHGSGIDNTHFGALKVKDAIVDKLRTPTGERPSIDKLNPDLRIHLRLDRGEAILSLDLSGHSLHQRGYRLQQGAAPLKENLAAAILIRAGWPRIAAEGGALADPMCGVGTFLVEAGMIAADMAPNLRRQQWGFTAWLGHVPALWKKLHEEATARAAAGLAKPPLWIRGYEADPRLIQPGRNNVERAGLSEWIKIYQGEVATFEPRPDQNQKGLVICNPPYGERLGDEASLLYLYQNLGERLRQACLNWEAAVFTGAPDLGKRMGIRSHKQYSFWNGALPCKLLLIKVLPDQFVTGERRTPEQRQAEREQAAYDQAPEVPQERQYNKNGNPIKPAPAPAPVVEQARLSEGGQMFANRLQKNLKLLSKWAKREGVDCYRVYDADMPEYSMAIDLYHDWVHVQEYVAPKSIDPEKASARLFDALAAIPQALNVDKSRVVIKRRERQSGTKQYERQSAQGKFTEVNEGGVKLLVNLTDYLDTGLFLDHRPMRLRIQKEAAGKRFLNLFCYTATASVHAAKGGARSTTSVDLSKTYLDWARRNLSLNGFSDKNRLEQGDVMAWLEASRDEYDLIFIDPPTFSNSKRMEGVFDVQRDHVQLLDLAMARLAPGGVLYFSNNFRKFQLEDNLGERYAVEEITAKTIDPDFARNGKIHRAWKIMAR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias395-409Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP012831
EMBL· GenBank· DDBJ
ALI05710.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help