A0A0N9SDB7 · A0A0N9SDB7_HHV8

Function

function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site200substrate
Binding site215-216substrate
Site216Important for hydrogen atom transfer
Binding site246substrate
Active site415Proton acceptor
Binding site415-419substrate
Active site417Cysteine radical intermediate
Active site419Proton acceptor
Site431Important for hydrogen atom transfer
Binding site606-610substrate
Site737Important for electron transfer
Site738Important for electron transfer
Site782Interacts with thioredoxin/glutaredoxin

GO annotations

AspectTerm
Cellular Componentribonucleoside-diphosphate reductase complex
Molecular FunctionATP binding
Molecular Functionribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Processdeoxyribonucleotide biosynthetic process
Biological ProcessDNA replication
Biological Processviral process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonucleoside-diphosphate reductase large subunit
  • EC number
  • Short names
    R1
  • Alternative names
    • Ribonucleotide reductase large subunit

Gene names

    • Name
      ORF61
    • Synonyms
      RIR1

Organism names

Accessions

  • Primary accession
    A0A0N9SDB7

PTM/Processing

Keywords

Expression

Keywords

Interaction

Subunit

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain584-606Ribonucleotide reductase large subunit
Region758-781Disordered

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    792
  • Mass (Da)
    88,761
  • Last updated
    2016-01-20 v1
  • Checksum
    C575BB5F220916E3
MSVRTFCQVHLGAVPPERRGSQVSAGQLSDFDMCAQSLIDFLKVRVGWDVRANAMAGRLWHQIMEARCPATLKQYLGIFRGVLGHRVESFIQKNIDALEDMLCAYRRSKAYEDTLNCGYLSAVRLYDTYVLRTMGTEPVYESVAQMFMRVSVFVACQCLEHECLYWLARDLIEDAKSVSEMAIVEYVFGYLAAQHVCCATPILRSAGVEGGQLASCFILQPSMMNESGTLDALYHDMSPLLASKSGVGLDVTSFSHQKNIASCLKLVDAQVHYFNDNNIRPVGASAYMELWHSQICDFLNAKLPENPDRCHSLFQGVCIPTLFFRMYEKDPSKLWYLFDPATAPNLIKLYGAAFDNEYERLVRAGKYVSCMPLKSMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMAINCSNLCAEIVQLPGRNTSVCNLANICLPKCLRTVESARVGTTDANRPFFCFEALGDAVRVAVLVINACILGGSHPTPGVERGQKERSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEGQGVPFHGWEVSNFAKGRFHWQTWEGEDASFVPRHRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKVTNKEEVLRPNVTFLKKVLPDDLRVVRQYGGDVSTFPKHHRERYRVFLTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDRVRNASYLRDLLLHGYRLGLKTLMYYCRVQKQSSLTALQCLADPGSPPHSGMKQDGAWLPGPKNPEEQSCAADPECLVCQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT271461
EMBL· GenBank· DDBJ
ALH44923.1
EMBL· GenBank· DDBJ
Genomic DNA
KT271463
EMBL· GenBank· DDBJ
ALH45099.1
EMBL· GenBank· DDBJ
Genomic DNA
MT510656
EMBL· GenBank· DDBJ
QLI55083.1
EMBL· GenBank· DDBJ
Genomic DNA
MT510657
EMBL· GenBank· DDBJ
QLI55172.1
EMBL· GenBank· DDBJ
Genomic DNA
MT510658
EMBL· GenBank· DDBJ
QLI55261.1
EMBL· GenBank· DDBJ
Genomic DNA
MT510670
EMBL· GenBank· DDBJ
QLI56329.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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