A0A0N9I0C6 · A0A0N9I0C6_9PSEU

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site113Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site114Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site152substrate
Binding site175substrate
Site185-186Cleavage; by autolysis
Active site186Nucleophile
Binding site186substrate
Binding site266substrate
Binding site385substrate
Binding site390substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetyl-CoA:L-glutamate N-acetyltransferase activity
Molecular Functionglutamate N-acetyltransferase activity
Molecular Functionmethione N-acyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      AOZ06_15335

Organism names

  • Taxonomic identifier
  • Strain
    • KLBMP1111
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Kibdelosporangium

Accessions

  • Primary accession
    A0A0N9I0C6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50233734011-185Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5023373402186-390Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    40,101
  • Last updated
    2016-01-20 v1
  • Checksum
    1E2A8225C9C227CF
MNRDKGVTGPAGFRAAGIAAGIKASGALDLTLVVNDGPGTAAAGVFTTNVVKAAPVLWSQQVLQQRSLKAVVLNSGGANACTGPEGFQDTHATAEKVAEGLGCGAIEVAVCSTGLIGERLPMGKVLSGVDTAVTALASDDQAGLHAATGVMTTDTRPKQSWKAHEQGWSIGGFVKGAGMLAPNLATMLSVITTDADLDKDTIDTALREATRMTFDRLDVDGGTSTNDTVLVLASGASGVRPSAGEFTALLTEVSADLVKQLQGDAEGVTKEIAITVTGAATEDEAVHIGRIVAEDNLVKTALFGSDPNWGRIAMALGRAKARIDPGQLSIIINGIRVMDKGTRGEDRENADLTGRDIDVVIDLAFGRGEATILTTDLSHAYVEENSAYSS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP012752
EMBL· GenBank· DDBJ
ALG08110.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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