A0A0N9GN02 · A0A0N9GN02_CHYAM

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Chymomyza

Accessions

  • Primary accession
    A0A0N9GN02

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-67Helical
Transmembrane87-113Helical
Transmembrane125-149Helical
Transmembrane169-194Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-196Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    196
  • Mass (Da)
    20,896
  • Last updated
    2016-01-20 v1
  • Checksum
    D697A132359CABDE
TLYFIFGAWSGMIGTSLSILIRAELGHPGALIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALTLLLVSSMVENGAGTGWTVYPPLSSGIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGITLDRMPLFVWSVVITALLLLLSLPVLAGAITMLLTD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue196

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT608137
EMBL· GenBank· DDBJ
ALF78350.1
EMBL· GenBank· DDBJ
Genomic DNA
KT609287
EMBL· GenBank· DDBJ
ALF79500.1
EMBL· GenBank· DDBJ
Genomic DNA
KR769322
EMBL· GenBank· DDBJ
AOA20828.1
EMBL· GenBank· DDBJ
Genomic DNA
KR773145
EMBL· GenBank· DDBJ
AOA24651.1
EMBL· GenBank· DDBJ
Genomic DNA
KR671412
EMBL· GenBank· DDBJ
AOD60650.1
EMBL· GenBank· DDBJ
Genomic DNA
MF875589
EMBL· GenBank· DDBJ
AXB23453.1
EMBL· GenBank· DDBJ
Genomic DNA
MF876602
EMBL· GenBank· DDBJ
AXB24466.1
EMBL· GenBank· DDBJ
Genomic DNA
MG080570
EMBL· GenBank· DDBJ
AXX78258.1
EMBL· GenBank· DDBJ
Genomic DNA
MG081013
EMBL· GenBank· DDBJ
AXX78701.1
EMBL· GenBank· DDBJ
Genomic DNA
MG087357
EMBL· GenBank· DDBJ
AXX82359.1
EMBL· GenBank· DDBJ
Genomic DNA
MF874513
EMBL· GenBank· DDBJ
AXZ69282.1
EMBL· GenBank· DDBJ
Genomic DNA
MF880684
EMBL· GenBank· DDBJ
AYM30079.1
EMBL· GenBank· DDBJ
Genomic DNA
MF881714
EMBL· GenBank· DDBJ
AYM31109.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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