A0A0N9EBT2 · A0A0N9EBT2_AEDVE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A0N9EBT2

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane34-64Helical
Transmembrane127-152Helical
Transmembrane164-191Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-193Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    193
  • Mass (Da)
    20,666
  • Last updated
    2016-01-20 v1
  • Checksum
    BFA3558690ED7539
FIFGVWSGMVGTSLSMLIRAELSHPGMFIGNDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWMLPPSLTLLLSSSMVENGAGTGWTVYPPLSSGTAHAGASVDLAIFSLHLAGISSILGAVNFITTVINMRSSGITLDRLPLFVWSVVITAILLLLSLPVLAGAITMLLTD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue193

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT603700
EMBL· GenBank· DDBJ
ALF42038.1
EMBL· GenBank· DDBJ
Genomic DNA
KM947857
EMBL· GenBank· DDBJ
ALP28361.1
EMBL· GenBank· DDBJ
Genomic DNA
KM953352
EMBL· GenBank· DDBJ
ALR53982.1
EMBL· GenBank· DDBJ
Genomic DNA
KM953409
EMBL· GenBank· DDBJ
ALR54039.1
EMBL· GenBank· DDBJ
Genomic DNA
KM953837
EMBL· GenBank· DDBJ
ALR54467.1
EMBL· GenBank· DDBJ
Genomic DNA
KM956230
EMBL· GenBank· DDBJ
ALR56859.1
EMBL· GenBank· DDBJ
Genomic DNA
KM959763
EMBL· GenBank· DDBJ
ALR60388.1
EMBL· GenBank· DDBJ
Genomic DNA
KM967551
EMBL· GenBank· DDBJ
ALR63451.1
EMBL· GenBank· DDBJ
Genomic DNA
KM968526
EMBL· GenBank· DDBJ
ALR64426.1
EMBL· GenBank· DDBJ
Genomic DNA
KR654916
EMBL· GenBank· DDBJ
AOD44154.1
EMBL· GenBank· DDBJ
Genomic DNA
KT104899
EMBL· GenBank· DDBJ
AOQ89204.1
EMBL· GenBank· DDBJ
Genomic DNA
MF821714
EMBL· GenBank· DDBJ
AWN86467.1
EMBL· GenBank· DDBJ
Genomic DNA
MF822274
EMBL· GenBank· DDBJ
AWN87027.1
EMBL· GenBank· DDBJ
Genomic DNA
MF822434
EMBL· GenBank· DDBJ
AWN87187.1
EMBL· GenBank· DDBJ
Genomic DNA
MF823659
EMBL· GenBank· DDBJ
AWN88412.1
EMBL· GenBank· DDBJ
Genomic DNA
MF824912
EMBL· GenBank· DDBJ
AWN89665.1
EMBL· GenBank· DDBJ
Genomic DNA
MF824964
EMBL· GenBank· DDBJ
AWN89717.1
EMBL· GenBank· DDBJ
Genomic DNA
MF825113
EMBL· GenBank· DDBJ
AWN89866.1
EMBL· GenBank· DDBJ
Genomic DNA
MF825205
EMBL· GenBank· DDBJ
AWN89958.1
EMBL· GenBank· DDBJ
Genomic DNA
MF819153
EMBL· GenBank· DDBJ
AWU61554.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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