A0A0N8GHG0 · A0A0N8GHG0_9BACI

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site59Zn2+ 1 (UniProtKB | ChEBI)
Binding site61Zn2+ 1 (UniProtKB | ChEBI)
Binding site61-63substrate
Binding site93substrate
Binding site151Zn2+ 2 (UniProtKB | ChEBI)
Binding site151Zn2+ 1 (UniProtKB | ChEBI)
Binding site178Zn2+ 2 (UniProtKB | ChEBI)
Binding site231Zn2+ 2 (UniProtKB | ChEBI)
Binding site277substrate
Active site304
Binding site304Zn2+ 1 (UniProtKB | ChEBI)
Binding site308substrate
Binding site322-323substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionallantoinase activity
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' UMP biosynthetic process
Biological Processpurine nucleobase catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • ORF names
      AM506_00735

Organism names

  • Taxonomic identifier
  • Strain
    • UCD-SED5
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Rossellomorea

Accessions

  • Primary accession
    A0A0N8GHG0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain50-420Amidohydrolase-related

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    428
  • Mass (Da)
    46,727
  • Last updated
    2016-01-20 v1
  • Checksum
    B90957307C53242B
MNWLIRNARIVTKNGELETVDVKVEEKKIIEIGSELKGKDHEEFQAEGLVISPGFVDLHVHLREPGGEYKETIETGTKSAAKGGFTTIAAMPNTRPVPDSVENLQSLNQKISDTAGVRVLPYAAITERQIGNKLNDLPSLKENGAFAFTDDGVGVQSADMMYQAMKMAAGINASIVAHCEENTLIYGGAVHDGTFSKEHNLPGIPSICEAVHISRDVLLAEAAGVHYHVCHISTKESVRVVRDAKKAGINVTAEVTPHHLLLSEDDIPGLDPNFKMNPPLRSKEDRQALIEGLLDGTIDFIATDHAPHTEAEKSEGMQLAPFGIVGLETAFPLLYTNFVEKGIFTLKQLIDWMTIKPSSAFNLPFGLLEVGGEADFTLIDLQEQKEIDPAGFVSKGKNTPFKGWECKGWPKATFYQGSLVWNEGGNEQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LIXZ01000001
EMBL· GenBank· DDBJ
KPL61194.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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