A0A0N7EHS8 · A0A0N7EHS8_9SAUR

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Colubridae > Colubrinae > Elaphe

Accessions

  • Primary accession
    A0A0N7EHS8

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane42-67Helical
Transmembrane88-110Helical
Transmembrane130-155Helical
Transmembrane167-194Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,642
  • Last updated
    2016-01-20 v1
  • Checksum
    7B624039DCEFE8A3
TLYLLFGAWSGLIGACLSIIMRMELTQPGSLLGSDQIFNVLVTAHAFIMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLLPPALLLLLSSSYVEAGAGTGWTVYPPLSGNLVHSGPSVDLAIFSLHLAGASSILGAINFITTCINMKPKSMPMFNIPLFVWSVLITAIMLLLALPVLAAAITMLLTDRNLNTSFFDPCGGGDPVLFQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KR046080
EMBL· GenBank· DDBJ
ALF07517.1
EMBL· GenBank· DDBJ
Genomic DNA
KR046081
EMBL· GenBank· DDBJ
ALF07518.1
EMBL· GenBank· DDBJ
Genomic DNA
KR046082
EMBL· GenBank· DDBJ
ALF07519.1
EMBL· GenBank· DDBJ
Genomic DNA
KR815553
EMBL· GenBank· DDBJ
ALL35015.1
EMBL· GenBank· DDBJ
Genomic DNA
KR815561
EMBL· GenBank· DDBJ
ALL35023.1
EMBL· GenBank· DDBJ
Genomic DNA
KR815562
EMBL· GenBank· DDBJ
ALL35024.1
EMBL· GenBank· DDBJ
Genomic DNA
MF099687
EMBL· GenBank· DDBJ
ASO75218.1
EMBL· GenBank· DDBJ
Genomic DNA
MF099688
EMBL· GenBank· DDBJ
ASO75219.1
EMBL· GenBank· DDBJ
Genomic DNA
MH153656
EMBL· GenBank· DDBJ
AYP30417.1
EMBL· GenBank· DDBJ
Genomic DNA
MH153660
EMBL· GenBank· DDBJ
AYP30421.1
EMBL· GenBank· DDBJ
Genomic DNA
MH220634
EMBL· GenBank· DDBJ
AYP30508.1
EMBL· GenBank· DDBJ
Genomic DNA
MH220641
EMBL· GenBank· DDBJ
AYP30515.1
EMBL· GenBank· DDBJ
Genomic DNA
MH220644
EMBL· GenBank· DDBJ
AYP30518.1
EMBL· GenBank· DDBJ
Genomic DNA
MH220648
EMBL· GenBank· DDBJ
AYP30522.1
EMBL· GenBank· DDBJ
Genomic DNA
MH220662
EMBL· GenBank· DDBJ
AYP30536.1
EMBL· GenBank· DDBJ
Genomic DNA
MK064678
EMBL· GenBank· DDBJ
QCQ65774.1
EMBL· GenBank· DDBJ
Genomic DNA
MK064679
EMBL· GenBank· DDBJ
QCQ65775.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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