A0A0N4Z2Q9 · A0A0N4Z2Q9_PARTI

Function

function

Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Functionhistone H3K79 trimethyltransferase activity
Molecular Functionmyosin phosphatase activity
Biological Processmethylation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Histone-lysine N-methyltransferase, H3 lysine-79 specific
  • EC number
  • Alternative names
    • Histone H3-K79 methyltransferase
  • Recommended name
    Serine/threonine-protein phosphatase
  • EC number

Organism names

Accessions

  • Primary accession
    A0A0N4Z2Q9

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane295-313Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain2-320DOT1
Region329-385Disordered
Compositional bias331-351Basic and acidic residues
Compositional bias997-1014Polar residues
Region997-1021Disordered

Sequence similarities

Belongs to the PPP phosphatase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,021
  • Mass (Da)
    116,319
  • Last updated
    2015-12-09 v1
  • Checksum
    3CA0A5C89CCE4615
MARIRLFQWCVLKSTKDFIPFCKDTSEFYLEEINLYTENAWNKKLPDSTIYFDFILFLGSMVQYDCDTRDYFAYKYKNIYPMPDQTPRGGSMDSDLADEVSNLLKAIITNRETVLKNYYQGSTEFTYGELKLQTLLELVNRSKMKFANENNFIDCGSGISNLQAGVAITQSVNSSIGVEINPLIGSAGKLYLHSFYLLARFANYSFSPTIHIIGDFNNNALDNLYNAKASIFFVNNFLLNDNTTLKLLDKISDTELSTTGIILTLNIGVGLRKFDYFANRKFEKQKFTLKDCVSWTKLYMMCFIVVIINSYFYQMFFANNSVFGTLTGQKSKNKNKDEIAGTTVKKRDNLIPKEKHKGKRKTKDKGSANHRTDGTDTSARASKNLPKCTVPVSLKGNDKIVIKKRTKEKTKEKSKEVGKETVKEVLKDKTNKEEDSNNNIKLKTSKTLGNDVEPITKIVGTKTQVPEVKPSPSIETNAKMKMEMKVTVPELKQMLKTCGDCKSGLLTYDLARSILIKAMEATKEYFKAEPLKRDGVGLKYLTPNEVQFILHRVTDILEQESVVLEITVPPEGMVVLSDLHGSLVDLLYNFKTYGIPPKKMYLFLGDYVDKGEDEVPLMFLLFCLKATYPDKMLLLRGNHEIVDMNRQKKFPAHCKEFFGDVAYFRMLNYVMERLPICAFVNDSLLCVHGGVSQWMKSREQLKAIKRPIKLNLDLVTRLVISDMLWSDPLNDNFDDTATFMFSPTLRGCGWAFSDIGLEAILKKLKLKKLLRGHQVCELGFNVDFQDTCITVHTKSMKKNNAKSGVVILTNSENQTNTCPIIDTQNYYVKMSNANIINILDILITSFNGTKEDNYNEKVFSSTCKHCSSTNYFKEISDSRRTLVTHTQLNKFLGTLAYKKLYKEETGRILNTANQKLVQVQIKRFPIYLDFLACPDDQFLRDIDLIANEEMDIYAKLKSIVKEKGEVVKCLNPKYDVLPMLNLLERVTKRKFNFTADESDVSEGSGESSSSHSKTLTSDTEE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias331-351Basic and acidic residues
Compositional bias997-1014Polar residues

Genome annotation databases

Similar Proteins

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