5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice.Irvin C.G., Tu Y.P., Sheller J.R., Funk C.D.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 87999PubMedEurope PMCAm J Physiol 272:L1053-8 (1997)Mapped to7
Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses.Byrum R.S., Goulet J.L., Griffiths R.J., Koller B.H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 87999PubMedEurope PMCJ Exp Med 185:1065-1075 (1997)Mapped to10
A transforming growth factor-beta regulable RNA-binding protein interacts specifically with germline Ig alpha transcripts.Edmiston J.S., Lebman D.A.View abstractCategoriesFunctionSourceMGI: 87999PubMedEurope PMCInt Immunol 9:427-433 (1997)Mapped to10
Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities.Bailie M.B., Standiford T.J., Laichalk L.L., Coffey M.J., Strieter R., Peters-Golden M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 87999PubMedEurope PMCJ Immunol 157:5221-5224 (1996)Mapped to7
The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice.Funk C.D.CategoriesFunctionSourceMGI: 87999PubMedEurope PMCBiochim Biophys Acta 1304:65-84 (1996)Mapped to14
Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions.Funk C.D., Kurre U., Griffis G.CategoriesFunctionSourceMGI: 87999PubMedEurope PMCAnn N Y Acad Sci 714:253-258 (1994)Mapped to30
Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene.Chen X.S., Sheller J.R., Johnson E.N., Funk C.D.View abstractCategoriesFunctionSourceMGI: 87999PubMedEurope PMCNature 372:179-182 (1994)Cited in1Mapped to6
Altered inflammatory responses in leukotriene-deficient mice.Goulet J.L., Snouwaert J.N., Latour A.M., Coffman T.M., Koller B.H.View abstractCategoriesFunctionSourceMGI: 87999PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 91:12852-12856 (1994)Cited in1Mapped to6
Leukotriene-deficient mice generated by targeted disruption of the 5- lipoxygenase gene.Funk C.D., Chen X.S., Kurre U., Griffis G.CategoriesFunctionSourceMGI: 87999PubMedEurope PMCAdv Prostaglandin Thromboxane Leukot Res 23:145-150 (1995)Mapped to7
cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase.Chen X.-S., Naumann T.A., Kurre U., Jenkins N.A., Copeland N.G., Funk C.D.View abstractCategoriesSequences, Subcellular LocationSourceMGI: 87999PubMedEurope PMCJ. Biol. Chem. 270:17993-17999 (1995)Cited in1Mapped to26
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance.Billipp T.E., Fung C., Webeck L.M., Sargent D.B., Gologorsky M.B., Chen Z., McDaniel M.M., Kasal D.N., McGinty J.W.[...], von Moltke J.View abstractSourceMGI: 87999PubMedEurope PMCImmunity 57:1243-1259.e8 (2024)Mapped to35
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease.Song S., Su Z., Kon N., Chu B., Li H., Jiang X., Luo J., Stockwell B.R., Gu W.View abstractSourceMGI: 87999PubMedEurope PMCGenes Dev 37:204-217 (2023)Mapped to10
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12- HETE.Pernet E., Sun S., Sarden N., Gona S., Nguyen A., Khan N., Mawhinney M., Tran K.A., Chronopoulos J.[...], Divangahi M.View abstractSourceMGI: 87999PubMedEurope PMCNature 614:530-538 (2023)Mapped to27
Transcellular biosynthesis of leukotriene B<sub>4</sub> orchestrates neutrophil swarming to fungi.Hopke A., Lin T., Scherer A.K., Shay A.E., Timmer K.D., Wilson-Mifsud B., Mansour M.K., Serhan C.N., Irimia D., Hurley B.P.View abstractSourceMGI: 87999PubMedEurope PMCiScience 25:105226-105226 (2022)Mapped to8
Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans.Pamplona F.A., Vitoria G., Sudo F.K., Ribeiro F.C., Isaac A.R., Moraes C.A., Chauvet M.G., Ledur P.F., Karmirian K.[...], Tovar-Moll F.View abstractCategoriesFunctionSourceMGI: 87999PubMedEurope PMCTransl Psychiatry 12:439-439 (2022)Mapped to7
Leukotrienes promote stem cell self-renewal and chemoresistance in acute myeloid leukemia.Stranahan A.W., Berezniuk I., Chakraborty S., Feller F., Khalaj M., Park C.Y.View abstractCategoriesFunction, ExpressionSourceMGI: 87999PubMedEurope PMCLeukemia 36:1575-1584 (2022)Mapped to7
Mice lacking 5-lipoxygenase display motor deficits associated with cortical and hippocampal synapse abnormalities.Barbosa-Silva M.C., P Campos R.M., Del Castilo I., Franca J.V., Frost P.S., Penido C., Clarke J.R., Canetti C., Ribeiro-Resende V.T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 87999PubMedEurope PMCBrain Behav Immun 100:183-193 (2022)Mapped to7
Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery.Penkert H., Bertrand A., Tiwari V., Breimann S., Muller S.A., Jordan P.M., Gerl M.J., Klose C., Cantuti-Castelvetri L.[...], Simons M.View abstractCategoriesFunctionSourceMGI: 87999PubMedEurope PMCCell Rep 37:109898-109898 (2021)Mapped to9
Alveolar socket healing in 5-lipoxygenase knockout aged female mice treated or not with high dose of zoledronic acid.Mahmoud R.H., Biguetti C.C., Simionato G.B., Custodio I.C., Silva R.B.P., Duarte M.A.H., Faverani L.P., Ervolino E., Fakhouri W.D., Matsumoto M.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 87999PubMedEurope PMCSci Rep 11:19535-19535 (2021)Mapped to7
A basophil-neuronal axis promotes itch.Wang F., Trier A.M., Li F., Kim S., Chen Z., Chai J.N., Mack M.R., Morrison S.A., Hamilton J.D.[...], Kim B.S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 87999PubMedEurope PMCCell 184:422-440.e17 (2021)Mapped to24
The LTB4-BLT1 axis regulates actomyosin and beta2-integrin dynamics during neutrophil extravasation.Subramanian B.C., Melis N., Chen D., Wang W., Gallardo D., Weigert R., Parent C.A.View abstractCategoriesFunctionSourceMGI: 87999PubMedEurope PMCJ Cell Biol 219:e201910215-e201910215 (2020)Mapped to16
New Surgical Model for Bone-Muscle Injury Reveals Age and Gender-Related Healing Patterns in the 5 Lipoxygenase (5LO) Knockout Mouse.Biguetti C.C., Couto M.C.R., Silva A.C.R., Shindo J.V.T.C., Rosa V.M., Shinohara A.L., Andreo J.C., Duarte M.A.H., Wang Z.[...], Matsumoto M.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 87999PubMedEurope PMCFront Endocrinol (Lausanne) 11:484-484 (2020)Mapped to7
COX Inhibition Increases <i>Alternaria</i>-Induced Pulmonary Group 2 Innate Lymphoid Cell Responses and IL-33 Release in Mice.Zhou W., Zhang J., Toki S., Goleniewska K., Norlander A.E., Newcomb D.C., Wu P., Boyd K.L., Kita H., Peebles R.S. Jr.View abstractCategoriesFunctionSourceMGI: 87999PubMedEurope PMCJ Immunol 205:1157-1166 (2020)Mapped to12
Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response.Rahabi M., Jacquemin G., Prat M., Meunier E., AlaEddine M., Bertrand B., Lefevre L., Benmoussa K., Batigne P.[...], Coste A.View abstractCategoriesFunctionSourceMGI: 87999PubMedEurope PMCCell Rep 30:4386-4398.e5 (2020)Mapped to32
Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity.McGinty J.W., Ting H.A., Billipp T.E., Nadjsombati M.S., Khan D.M., Barrett N.A., Liang H.E., Matsumoto I., von Moltke J.View abstractCategoriesFunctionSourceMGI: 87999PubMedEurope PMCImmunity 52:528-541.e7 (2020)Mapped to49