A0A0N1PE74 · A0A0N1PE74_LEPSE
- ProteinAminomethyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids377 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The glycine cleavage system catalyzes the degradation of glycine.
Catalytic activity
- N6-[(R)-S8-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 203 | substrate | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | glycine cleavage complex | |
Cellular Component | mitochondrion | |
Molecular Function | aminomethyltransferase activity | |
Molecular Function | methyltransferase activity | |
Molecular Function | transaminase activity | |
Biological Process | glycine catabolic process | |
Biological Process | methylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAminomethyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leptomonas
Accessions
- Primary accessionA0A0N1PE74
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Subunit
The glycine cleavage system is composed of four proteins: P, T, L and H.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-260 | Aminomethyltransferase folate-binding | ||||
Sequence: LHGYHLAQKAKMEGFAGYHMPISYPKMGVLKEHIYTREMAGIFDVSHMGQYEIRGADRERFMEYVTPVDLKKSQPGHASLTFLSNEKGGIKDDCIVTKMDDHLFLVLNAGCKVKDVAHIEDVLRNSPQMRGADVHFTPLERSLIALQGPKAASILSEFVDGVPDMDFMSCRQEVNVKGMRLQITRCGYTGEDGFEISVADKDALPLVELFLSKKAEMIGLGARDSLRLEAGLNLYGHELSEDTNPVAARFMW | ||||||
Domain | 295-368 | Glycine cleavage T-protein C-terminal barrel | ||||
Sequence: VGLVSTGPVARLHTVIKADGKEVGYVTSGCPSPCLKKNIALGYVDRDLAKKGTKVELVVRDRLVPAEIVTPPFV |
Sequence similarities
Belongs to the GcvT family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length377
- Mass (Da)41,779
- Last updated2015-12-09 v1
- Checksum03635DC4E3882ACD
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LJSK01000118 EMBL· GenBank· DDBJ | KPI86720.1 EMBL· GenBank· DDBJ | Genomic DNA |