A0A0N1PDG5 · A0A0N1PDG5_LEPSE

  • Protein
    4-hydroxybenzoate polyprenyltransferase, mitochondrial
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Function4-hydroxybenzoate polyprenyltransferase activity
Biological Processisoprenoid biosynthetic process
Biological Processubiquinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxybenzoate polyprenyltransferase, mitochondrial
  • EC number
  • Short names
    4-HB polyprenyltransferase
  • Alternative names
    • Para-hydroxybenzoate--polyprenyltransferase
      (PHB:PPT
      ; PHB:polyprenyltransferase
      )

Gene names

    • ORF names
      ABL78_2042

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ATCC 30220
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leptomonas

Accessions

  • Primary accession
    A0A0N1PDG5

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane91-110Helical
Transmembrane116-138Helical
Transmembrane193-211Helical
Transmembrane223-244Helical
Transmembrane250-270Helical
Transmembrane354-372Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the UbiA prenyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    489
  • Mass (Da)
    54,495
  • Last updated
    2015-12-09 v1
  • Checksum
    234FBD8BC4463490
MFRRTPYWPKVARSWTAASISAASAHFPDAVRADPAASRCGATSAKETRNWSLDDKTVKTAELPKVIALAVKRAKLYGDLVRFTRPVGWQLLLIPCYWGSALAVTRAIVWEGADPAALFAPFIPLHLAVQFLFGAYLMRSAGCVVNDMWDRKYDRLVERTAQRPLACGAVSMTEAWGVIISHVTLAALIALNLSPAALTACVAITPIWVMYPFMKRITYAPQFFLGLCFNWGIFVGYAAVLGRVDWAICLPMYCGAVVWTILYDTIYAYQDRRDDLNCGVKSTAIWIGDRKHILSGMVAPIGAGMLLTGFMVSQALPFYVGILMCMYRLHGIVDDVNIYDSWSCAQGFKRNVRLGVYVLLAMCVGNLFWAFASEHEAERDKALDSAPQSSLLSRFLFLDQHAEHRAYNTESFNWVDRVVHPAFVQAESAKAAGSSEAPPIPTWMRREYLGENVSTILLFCGVPEEKVAAWAAKWYALSDHYNMFSKISI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LJSK01000038
EMBL· GenBank· DDBJ
KPI88848.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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