A0A0N1PDG5 · A0A0N1PDG5_LEPSE
- Protein4-hydroxybenzoate polyprenyltransferase, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids489 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Catalytic activity
- an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate
an all-trans-polyprenyl diphosphate RHEA-COMP:9564 + CHEBI:17879 = a 4-hydroxy-3-all-trans-polyprenylbenzoate RHEA-COMP:9514 + CHEBI:33019
Cofactor
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | 4-hydroxybenzoate polyprenyltransferase activity | |
Biological Process | isoprenoid biosynthetic process | |
Biological Process | ubiquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxybenzoate polyprenyltransferase, mitochondrial
- EC number
- Short names4-HB polyprenyltransferase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leptomonas
Accessions
- Primary accessionA0A0N1PDG5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 91-110 | Helical | ||||
Sequence: LLLIPCYWGSALAVTRAIVW | ||||||
Transmembrane | 116-138 | Helical | ||||
Sequence: AALFAPFIPLHLAVQFLFGAYLM | ||||||
Transmembrane | 193-211 | Helical | ||||
Sequence: LSPAALTACVAITPIWVMY | ||||||
Transmembrane | 223-244 | Helical | ||||
Sequence: FFLGLCFNWGIFVGYAAVLGRV | ||||||
Transmembrane | 250-270 | Helical | ||||
Sequence: LPMYCGAVVWTILYDTIYAYQ | ||||||
Transmembrane | 354-372 | Helical | ||||
Sequence: LGVYVLLAMCVGNLFWAFA |
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length489
- Mass (Da)54,495
- Last updated2015-12-09 v1
- Checksum234FBD8BC4463490
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LJSK01000038 EMBL· GenBank· DDBJ | KPI88848.1 EMBL· GenBank· DDBJ | Genomic DNA |