A0A0N1NYY8 · A0A0N1NYY8_9EURO

  • Protein
    Adenine deaminase
  • Gene
    AAH1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site19Zn2+ (UniProtKB | ChEBI); catalytic
Binding site21Zn2+ (UniProtKB | ChEBI); catalytic
Binding site196Zn2+ (UniProtKB | ChEBI); catalytic
Active site199Proton donor
Site220Important for catalytic activity
Binding site277Zn2+ (UniProtKB | ChEBI); catalytic
Binding site278substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Function2'-deoxyadenosine deaminase activity
Molecular Functionadenine deaminase activity
Molecular Functionadenosine deaminase activity
Molecular Functionzinc ion binding
Biological Processadenine catabolic process
Biological Processhypoxanthine salvage
Biological Processnucleotide metabolic process
Biological Processpurine ribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenine deaminase
  • EC number
  • Short names
    ADE
  • Alternative names
    • Adenine aminohydrolase
      (AAH
      )

Gene names

    • Name
      AAH1
    • ORF names
      AB675_11864

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 131958
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Herpotrichiellaceae > Phialophora

Accessions

  • Primary accession
    A0A0N1NYY8

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-330Adenosine deaminase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    337
  • Mass (Da)
    37,968
  • Last updated
    2015-12-09 v1
  • Checksum
    4755EB9070FDB4EE
MCKSPLHSLIAELPKCEHHLHLEGCLTPALLFQLAAKNNINLPSQDEYQSQEALEKRYSHFTNLSDFLQYYYRALTILITASDFEQLAWSYFQTAHHDGVQHAEVFFDPQSHTSRGVKLETVVEGFKAACERARREFGITSCLIMCFLRHLPLEDAAETMDEAVRGGYFEGGGDQGRIFTSVYAKAKELGVHRTAHAGEEGDPSYIAAALDSLGVERIDHGVRLAEDPALMRRVVAEGLLLTVCPLSNVCLQVVQKVGQLPIRDFLKAGVKFSINSDDPAYFGGYVLDNYCAVQEAFDLAIDEWRQIVTNSIECSWIKKERKSELMSNLNRVLDRYR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LFJN01000028
EMBL· GenBank· DDBJ
KPI36786.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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