A0A0N1NYY8 · A0A0N1NYY8_9EURO
- ProteinAdenine deaminase
- GeneAAH1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids337 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
Catalytic activity
- adenine + H2O + H+ = hypoxanthine + NH4+
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 19 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 21 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 196 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 199 | Proton donor | |||
Site | 220 | Important for catalytic activity | |||
Binding site | 277 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 278 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | 2'-deoxyadenosine deaminase activity | |
Molecular Function | adenine deaminase activity | |
Molecular Function | adenosine deaminase activity | |
Molecular Function | zinc ion binding | |
Biological Process | adenine catabolic process | |
Biological Process | hypoxanthine salvage | |
Biological Process | nucleotide metabolic process | |
Biological Process | purine ribonucleoside monophosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenine deaminase
- EC number
- Short namesADE
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Herpotrichiellaceae > Phialophora
Accessions
- Primary accessionA0A0N1NYY8
Proteomes
Organism-specific databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 14-330 | Adenosine deaminase | |||
Sequence similarities
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length337
- Mass (Da)37,968
- Last updated2015-12-09 v1
- Checksum4755EB9070FDB4EE
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LFJN01000028 EMBL· GenBank· DDBJ | KPI36786.1 EMBL· GenBank· DDBJ | Genomic DNA |