A0A0N1I695 · A0A0N1I695_LEPSE

  • Protein
    Deoxyhypusine hydroxylase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the hydroxylation of the N6-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.
Catalyzes the hydroxylation of the N6-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 2 Fe2+ ions per subunit.

Pathway

Protein modification; eIF5A hypusination.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site63Fe cation 1 (UniProtKB | ChEBI)
Binding site64Fe cation 1 (UniProtKB | ChEBI)
Binding site96Fe cation 1 (UniProtKB | ChEBI)
Binding site97Fe cation 1 (UniProtKB | ChEBI)
Binding site234Fe cation 2 (UniProtKB | ChEBI)
Binding site235Fe cation 2 (UniProtKB | ChEBI)
Binding site267Fe cation 2 (UniProtKB | ChEBI)
Binding site268Fe cation 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyhypusine monooxygenase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyhypusine hydroxylase
  • EC number
  • Short names
    DOHH
  • Alternative names
    • Deoxyhypusine dioxygenase
    • Deoxyhypusine monooxygenase

Gene names

    • ORF names
      ABL78_2273

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ATCC 30220
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leptomonas

Accessions

  • Primary accession
    A0A0N1I695

Proteomes

Organism-specific databases

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat248-288HEAT

Sequence similarities

Belongs to the deoxyhypusine hydroxylase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    335
  • Mass (Da)
    36,669
  • Last updated
    2015-12-09 v1
  • MD5 Checksum
    28C852189559951361CBE25D905EFD81
MSASTLTLEEVRKNYAKLLDPQEPLDSRMRELYRLKEDCLKTLPGVQVLLEAIDTTDSVLLQHELAYNAGQSGREEAVPELERILRTTSYDVVTRHEAAEALGAIGSTLALKVLEEHGDPAKEPEEAIRETCELALARIAMKEKKGDRAVAPPSDCAFVSVDPSPAFNEMLEGDEPVPKTVDELAEVLLDTSGRTRLFRRYMAMFTLRNMANDAAVAALSRALREDTVSALFRHEVAFVLGQLEHPKSQPALIEALKDETEAPMVRHEAAEALGAIADPATLPVLETYATHSEPIVRDSCVVALEMHKYWANFNNLGNQPVAEGEKTDAGAVAAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LJSK01000045
EMBL· GenBank· DDBJ
KPI88605.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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