A0A0N1I2F2 · A0A0N1I2F2_LEPSE

  • Protein
    MORN repeat-containing protein 3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors. May play a role in the regulation of spermatogenesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site.

1738100200300400500600700
TypeIDPosition(s)Description
Binding site99-106ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacrosomal vesicle
Molecular FunctionATP binding
Molecular Functionmicrotubule binding
Molecular Functionmicrotubule motor activity
Biological Processmicrotubule-based movement

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    MORN repeat-containing protein 3

Gene names

    • ORF names
      ABL78_1255

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ATCC 30220
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leptomonas

Accessions

  • Primary accession
    A0A0N1I2F2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain18-220Kinesin motor
Region441-470Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    738
  • Mass (Da)
    82,533
  • Last updated
    2015-12-09 v1
  • MD5 Checksum
    1E6347E4BE8192A2A8CA038DA6D0EDFE
MATYKPPQLSVHPPVVERLRIAVRERPASDIEVASTQVMLRADQDKLIAFAPNASDGLMYDFDYFYPQTARQEDVFRTIGLEMVDLVMGGLSANCIAVGFAETGKTHTLFGSADEPSLIRETVRELFFRLEELADKQEYTVGFSYWEMNCNAVHDNLSDLPTTASTAYGDADASGKGEASSDHAVYRDVLGHLYLSNLREAPVSNYDEFEALLNEGNKRRIQRGYARQFRWHGFVQLFLTTVDKQAGEQCVLRRLTFVHTKGPERVGANRAPKPILRQGSLINVSSTLLGAAVIHSLEYRSKRAARCHTQAQLHDLIQRSESFFMECCYTQVMSQLMCGHEASFVLGCVDPLSYRETIDTLENLQLFRQLDAACIPMVMPSERGRLLRQLRAMEAAVGGEEVLQSIYNEANGRPRTEQEEALLALRGRVEGWEQTDARLLRHGATPTTLDSHSRGSPKVRKGEDSNGRSTRTIVYLNPAKTATYEGQWKDNLFDGFGEHVQSNFKYHGFFCAGKREGQGTLFMRESKDSPYRRVYEGEWLAGCRDGRGTQWQPDGEVYEGDFAADERHGCGKLYCTNGDIVEGSFRHNKCEGWAVLRQAGGDWFEGYWLNGEREGPGAWHYVSRQRCLRGEWHHNKAVMGTMEDDTDKMDDSTGAFIPRLGLLDSDGVLANEKEKLMEKRRFEFAAAGKTWVDYAAMNSNSGSSSGICPSSAAVHSEPEGVATAATTTSNAVYGLEIE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LJSK01000020
EMBL· GenBank· DDBJ
KPI89590.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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