A0A0M9G2G6 · A0A0M9G2G6_LEPPY
- ProteintRNA 4-demethylwyosine synthase (AdoMet-dependent)
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids878 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- N1-methylguanosine37 in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine37 in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
RHEA-COMP:10165 CHEBI:73542 Position: 37+ CHEBI:15361 + CHEBI:59789 = RHEA-COMP:10164 CHEBI:64315 Position: 37+ CHEBI:17319 + CHEBI:57844 + CHEBI:16526 + CHEBI:15377
Cofactor
Pathway
tRNA modification; wybutosine-tRNA(Phe) biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | FMN binding | |
Molecular Function | lyase activity | |
Molecular Function | metal ion binding | |
Biological Process | wybutosine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA 4-demethylwyosine synthase (AdoMet-dependent)
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leptomonas
Accessions
- Primary accessionA0A0M9G2G6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-25 | ||||
Chain | PRO_5007419039 | 26-878 | tRNA 4-demethylwyosine synthase (AdoMet-dependent) | ||
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 80-101 | Disordered | |||
Domain | 115-317 | Flavodoxin-like | |||
Region | 167-189 | Disordered | |||
Region | 405-430 | Disordered | |||
Compositional bias | 408-430 | Acidic residues | |||
Domain | 503-748 | Radical SAM core | |||
Sequence similarities
Belongs to the TYW1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length878
- Mass (Da)96,746
- Last updated2015-12-09 v1
- ChecksumF3179EB26570D2E0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 408-430 | Acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LGTL01000007 EMBL· GenBank· DDBJ | KPA80857.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LGTL01000007 EMBL· GenBank· DDBJ | KPA80858.1 EMBL· GenBank· DDBJ | Genomic DNA |