A0A0M9G2B3 · A0A0M9G2B3_LEPPY

Function

function

Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site61FAD (UniProtKB | ChEBI)
Binding site127FAD (UniProtKB | ChEBI)
Binding site160-162FAD (UniProtKB | ChEBI)
Binding site195-202NAD+ (UniProtKB | ChEBI)
Binding site286NAD+ (UniProtKB | ChEBI)
Binding site327FAD (UniProtKB | ChEBI)
Active site461Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionglutathione-disulfide reductase (NADPH) activity
Molecular Functiontrypanothione-disulfide reductase (NADPH) activity
Biological Processcell redox homeostasis
Biological Processcellular response to oxidative stress
Biological Processglutathione metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Trypanothione reductase
  • EC number
  • Alternative names
    • N(1),N(8)-bis(glutathionyl)spermidine reductase

Gene names

    • ORF names
      ABB37_04236

Organism names

Accessions

  • Primary accession
    A0A0M9G2B3

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond52↔57Redox-active

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-342FAD/NAD(P)-binding
Domain363-468Pyridine nucleotide-disulphide oxidoreductase dimerisation

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    491
  • Mass (Da)
    53,101
  • Last updated
    2015-12-09 v1
  • MD5 Checksum
    F58AEFF41417E1841998F2BD01DA32E0
MSRAYDLVVIGAGSGGLEAGWNAAALHKKKVAVIDVQKTHGPPYFAALGGTCVNVGCVPKKLMVTGAGYMDTIRESAGFGWELDRDSVKPNWHTLIAAKNKAVLDINHSYEGMFADTEGLSFHQGFGAIADRNTVVVRQSEDPQSAVLETLDTDYILIATGSWPQRLGVPGDELCITSNEAFYLEEAPKNPLCVGGGYISVEFAGIFNAYKPRGGQVNLVYRKEVILRGFDLEVRKQLTEQLRANGIQIRTGDNPAKITKNADGTKHVVFESGVEADYDQVMLAIGRVPRSHTLQLDKVGVEVAKGGAVKVDKYSKTNIDNIYAIGDVTNRLMLTPVAINEGGAFVETVFGHNPTATDHAKVACAVFSIPPIGTCGYIEEDAAKKYDQVAVYESSFTPLLHNVSGSTYKKFMIRIVTNHADGEVLGVHMLGDSAPEIIQSVGICMKMGAKISDFYSTIGVHPTSAEELCSMRTPAYFYEKGHRVEKIGSNL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LGTL01000007
EMBL· GenBank· DDBJ
KPA80793.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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