A0A0M9ESU0 · A0A0M9ESU0_FUSLA

  • Protein
    Kynurenine formamidase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site135Nucleophile
Active site228
Active site260

GO annotations

AspectTerm
Molecular Functionarylformamidase activity
Molecular Functionlipase activity
Biological Process'de novo' NAD biosynthetic process from tryptophan
Biological Processtryptophan catabolic process to kynurenine

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Kynurenine formamidase
  • EC number
  • Short names
    KFA
    ; KFase
  • Alternative names
    • Arylformamidase
    • N-formylkynurenine formamidase
      (FKF
      )

Gene names

    • ORF names
      FLAG1_07965

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Fl201059
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium

Accessions

  • Primary accession
    A0A0M9ESU0

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, motif.

Type
IDPosition(s)Description
Domain36-206BD-FAE-like
Motif48-52HGGXW

Domain

The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.

Sequence similarities

Belongs to the kynurenine formamidase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    285
  • Mass (Da)
    31,602
  • Last updated
    2015-12-09 v1
  • Checksum
    DD7AEC65F0AF553E
MADIAADMSLGLTYASHQYGDHSRQKLGVWRFSNRSDQKSGHWVVFIHGGGWRDPRNNENDFTESIKRIVISGAVATLDIAGFISIDYRLSPHPEFPQEAASAKHPDHLEDVWSALNYAQENYGLSENYILVGHSAGATLAMQLLMSDEILPSHPKGPLPTAIIGVSGIYDLVGLNERFNGGYSGFIGSAFGEDKSEWEKASPAKFGSSLESKWSNGKLVLLAWSPEDGLIDEPEIDNMATLLTKQEVNLEVNKDLRGEHDYVWQDGSQIARLVITTLHHLRRML

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JXCE01000213
EMBL· GenBank· DDBJ
KPA39179.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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