A0A0M8ZSR0 · A0A0M8ZSR0_9HYME

Function

function

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionpoly-ADP-D-ribose binding
Molecular Functionubiquitin protein ligase activity
Molecular Functionzinc ion binding
Biological Processprotein autoubiquitination
Biological Processregulation of macromolecule metabolic process
Biological Processubiquitin-dependent protein catabolic process
Biological ProcessWnt signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase
  • EC number

Gene names

    • ORF names
      WN51_05633

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 0111107301
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Hymenoptera > Apocrita > Aculeata > Apoidea > Anthophila > Apidae > Melipona

Accessions

  • Primary accession
    A0A0M8ZSR0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Post-translational modification

Ubiquitinated; autoubiquitinated.

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-25Disordered
Domain35-73RING-type
Domain91-167WWE
Region244-351Disordered
Compositional bias249-263Basic and acidic residues
Compositional bias271-296Polar residues

Domain

The WWE domain mediates non-covalent poly(ADP-ribose)-binding.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    40,444
  • Last updated
    2015-12-09 v1
  • Checksum
    89FA7BCDA7CD3120
MAQAKLNSQEETSSTRNDKEKETDEKEGLTTVLECAVCLQPCIYPARLPCNHIYCYLCVKGVANQSKRCPMCRQEIPPDFLNRPQLVEVDEAQKESEHFEEEYQWFYEGRNGWWKYDSRTSQDLETIYNLGSAQCEILICGMLYVIDFKNNCQYRKHQPYYKRNIKRDRKNAPCKGWWQYDQRTSHELETAYKQGKRNCELLIAGFLYIADFGSMLQLRRNDPSRRRKIKRDLYNVPKKGVAGLRLNNQDEEITREVRGAERPASPASDDMGTGDGTNTPVPPSNTPQTPAGGTASGDATPLNDRMEQRDSLHQVLEQMRSLVLREHLSSDTDDELEEDEESESPSTHPTL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias249-263Basic and acidic residues
Compositional bias271-296Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KQ435875
EMBL· GenBank· DDBJ
KOX70197.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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