A0A0M6X1M4 · A0A0M6X1M4_9FIRM
- ProteinPolyamine aminopropyltransferase
- GenespeE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids285 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Catalytic activity
- putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H+ + S-methyl-5'-thioadenosine + spermidine
Pathway
Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 31 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 86 | spermidine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 106 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 137-138 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | ||||
Sequence: DG | ||||||
Active site | 155 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 155-158 | spermidine (UniProtKB | ChEBI) | ||||
Sequence: DSTD |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | spermidine synthase activity | |
Biological Process | spermidine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePolyamine aminopropyltransferase
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Roseburia
Accessions
- Primary accessionA0A0M6X1M4
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-237 | PABS | ||||
Sequence: QMWFSEYHTVNVKLDVRIEEQLFSGKSEYQKIDVFKSYEFGKMAALDGEIVFSDADEFIYDEMVTHVPMAVHPNAKKILIIGGGDGGVAKELIKYPFVEKIDVVETDKMFVDVCRKFFPEVACGLEDPRISMYYDDGLRFLRGKNDEYDLIINDSTDPLGHTEGLFTKEFYGSCYKALREDGIMVYQHGSPFYDEDEAECRKMHRKVYKSFPISRVYQAHIPTCPSGYWLFGFASK |
Sequence similarities
Belongs to the spermidine/spermine synthase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length285
- Mass (Da)33,234
- Last updated2015-12-09 v1
- Checksum4E804BBB0624B13F
Keywords
- Technical term