A0A0M4R4M4 · A0A0M4R4M4_CANSA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper A center.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2

Gene names

    • Name
      cox2

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Rosales > Cannabaceae > Cannabis

Accessions

  • Primary accession
    A0A0M4R4M4

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane42-62Helical
Transmembrane83-105Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-16
ChainPRO_500741816317-259Cytochrome c oxidase subunit 2

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-111Cytochrome oxidase subunit II transmembrane region profile
Domain113-250Cytochrome oxidase subunit II copper A binding

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    259
  • Mass (Da)
    29,465
  • Last updated
    2015-12-09 v1
  • Checksum
    A102F44AFE2CBB17
MIVLEWLFLTISPCDAAEPWQLGFQDAATPMMQGIIDLHHDIFFFLILILVFVSRILVRALWHFHYQKNPIPQRIVHGTTIEILWTIFPSIILMFIAIPSFALLYSMDEVVVDPAITIKAIGHQWYWTYEYSDYNSSDEESLTFDSYMIPEDDLELGQLRLLEVDNRVVVPAKTHLRIIVTSADVLHSWAVPSLGVKCDAVPGRLNQISILVQREGVYYGQCSEICGTNHAFSIVVEAVPRKDYGSRVSNQLIPQTGEA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KR059940
EMBL· GenBank· DDBJ
ALF04049.1
EMBL· GenBank· DDBJ
Genomic DNA
KU310670
EMBL· GenBank· DDBJ
AMR97537.1
EMBL· GenBank· DDBJ
Genomic DNA
KU363807
EMBL· GenBank· DDBJ
ANC49121.1
EMBL· GenBank· DDBJ
Genomic DNA
MN599027
EMBL· GenBank· DDBJ
QJE38179.1
EMBL· GenBank· DDBJ
Genomic DNA
MT361980
EMBL· GenBank· DDBJ
QJI81309.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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