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A0A0M4MWK7 · A0A0M4MWK7_9ACTN

Function

function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Feedback inhibited by histidine.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP phosphoribosyltransferase
  • EC number
  • Short names
    ATP-PRT
    ; ATP-PRTase

Gene names

    • Name
      hisG
    • ORF names
      AL705_00155
      , LC603019_00034

Organism names

  • Taxonomic identifier
  • Strains
    • X1698
    • USB-603019
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Lawsonellaceae > Lawsonella

Accessions

  • Primary accession
    A0A0M4MWK7

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-196ATP phosphoribosyltransferase catalytic
Domain211-282Histidine biosynthesis HisG C-terminal

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    286
  • Mass (Da)
    30,930
  • Last updated
    2015-12-09 v1
  • MD5 Checksum
    891A51F8AAC28091BA588C59E9F764BD
MLRIAIPNKGALSEPAQEMLKEAGYRTRADRKDLTVVDSSNGVEFFFLRPKDIAIYVGSGQLDLGITGRDLAIESQAPVRERLGLGFGGSNFRYAAPAHEEWSVEQIEGKTIASAYPNLTRADLASRGISATVIRLDGAVEISIQLGVADCIADIVESGRTLRAHGLAPFGEPLCVSEAVLIERDSTKEDTPELARAKETLAGRLQGVSYAKKYLMLDYDCPRELLDEAIALTPGLQYPTVSPLSNDGWCAVRAMVPRKGINALMDELHTLGASAILASDLRTCRL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP012390
EMBL· GenBank· DDBJ
ALE18406.1
EMBL· GenBank· DDBJ
Genomic DNA
LR584267
EMBL· GenBank· DDBJ
VHN99444.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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