A0A0M4FAV4 · A0A0M4FAV4_BOVIN
- ProteinNatural resistance-associated macrophage protein 1
- GeneNramp1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids548 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
Catalytic activity
- Fe2+(in) + H+(out) = Fe2+(out) + H+(in)
- Mn2+(in) + H+(out) = Mn2+(out) + H+(in)
- Zn2+(in) + H+(out) = Zn2+(out) + H+(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | late endosome membrane | |
Cellular Component | lysosomal membrane | |
Molecular Function | metal ion transmembrane transporter activity | |
Biological Process | iron ion transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNatural resistance-associated macrophage protein 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A0M4FAV4
Subcellular Location
UniProt Annotation
GO Annotation
Late endosome membrane ; Multi-pass membrane protein
Lysosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 81-102 | Helical | |||
Transmembrane | 133-159 | Helical | |||
Transmembrane | 165-184 | Helical | |||
Transmembrane | 196-218 | Helical | |||
Transmembrane | 238-256 | Helical | |||
Transmembrane | 277-303 | Helical | |||
Transmembrane | 342-368 | Helical | |||
Transmembrane | 395-414 | Helical | |||
Transmembrane | 434-452 | Helical | |||
Transmembrane | 464-486 | Helical | |||
Transmembrane | 492-513 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length548
- Mass (Da)59,450
- Last updated2015-12-09 v1
- MD5 ChecksumA6E28BB97A44F757AED9773E0DD5C1D7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KR002420 EMBL· GenBank· DDBJ | ALC78258.1 EMBL· GenBank· DDBJ | Genomic DNA |