A0A0M4FAV4 · A0A0M4FAV4_BOVIN

  • Protein
    Natural resistance-associated macrophage protein 1
  • Gene
    Nramp1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentlate endosome membrane
Cellular Componentlysosomal membrane
Molecular Functionmetal ion transmembrane transporter activity
Biological Processiron ion transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Natural resistance-associated macrophage protein 1
  • Alternative names
    • Solute carrier family 11 member 1

Gene names

    • Name
      Nramp1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • A2
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    A0A0M4FAV4

Subcellular Location

Late endosome membrane
; Multi-pass membrane protein
Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane81-102Helical
Transmembrane133-159Helical
Transmembrane165-184Helical
Transmembrane196-218Helical
Transmembrane238-256Helical
Transmembrane277-303Helical
Transmembrane342-368Helical
Transmembrane395-414Helical
Transmembrane434-452Helical
Transmembrane464-486Helical
Transmembrane492-513Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-38Disordered

Sequence similarities

Belongs to the NRAMP family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    548
  • Mass (Da)
    59,450
  • Last updated
    2015-12-09 v1
  • MD5 Checksum
    A6E28BB97A44F757AED9773E0DD5C1D7
MSGDTGPPKQGGTRYGSISSPPSPEPQQAPPGGTYLSEKIPIPDTESGAFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTIELAIVGSDMQEVIGTAIAFSLLSAGRIPLWGGVLITVVDTFFFLFLDNYGLRKLEAFFGFLITIMALTFGYETVVAQPAQGALLQGLFLPSCPGCGQPELLQAVGIIGAIIMPHNIYLHSSLVKSREVDRSRRADIREANMYFLIEATIALSVSFLINLFVMAVFGQAFYKQTNQAAFNICADSSLHDYAPIFPRNNLTVAVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRWSRFARVLLTRSCAILPTVLLAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPALMQEFANGLVSKVITSSIMVLVCAVNLYFVISYLPSLPHPAYFSLVALLAAAYLGLTTYLVWTCLITQGATLLAHSSHQRFLYGLPEEDQEKGRTSG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KR002420
EMBL· GenBank· DDBJ
ALC78258.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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