A0A0M3V4A2 · A0A0M3V4A2_9NOSO

  • Protein
    Bifunctional pantoate ligase/cytidylate kinase
  • Gene
    panC/cmk
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site48-55ATP (UniProtKB | ChEBI)
Active site55Proton donor
Binding site79(R)-pantoate (UniProtKB | ChEBI)
Binding site79beta-alanine (UniProtKB | ChEBI)
Binding site172-175ATP (UniProtKB | ChEBI)
Binding site178(R)-pantoate (UniProtKB | ChEBI)
Binding site201ATP (UniProtKB | ChEBI)
Binding site209-212ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionCMP kinase activity
Molecular FunctiondCMP kinase activity
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process
Biological Processphosphorylation
Biological Processpyrimidine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional pantoate ligase/cytidylate kinase

Including 2 domains:

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme
  • Recommended name
    Cytidylate kinase
  • EC number
  • Short names
    CK
  • Alternative names
    • Cytidine monophosphate kinase
      (CMP kinase
      )

Gene names

    • Name
      panC/cmk
    • ORF names
      ACX27_01255

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CENA21
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Nostocaceae > Nostoc

Accessions

  • Primary accession
    A0A0M3V4A2

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-302Pantoate--beta-alanine ligase
Region303-534Cytidylate kinase
Domain311-529Cytidylate kinase

Sequence similarities

Belongs to the cytidylate kinase family. Type 1 subfamily.
Belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.
In the N-terminal section; belongs to the pantothenate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    534
  • Mass (Da)
    58,711
  • Last updated
    2015-12-09 v1
  • Checksum
    0F2686A1EB79E5C2
MRLLTTVAALRCYLNKLRSDSQLTVSEELVADEMSSWDRTAVGLVPTMGGLHQGHLNLIKRARQENSTVIVSIFVNPLQFGPNEDYARYPRTLEQDQKLCENAGVDAIFAPTPEVMGVGAKNIQDSLITQVIPPSAMILGLCGRSRLGHFQGVATIVTKLLNLVQPDRAYFGQKDGQQLAIIKRLVADLNLPVEIVACPTVREASGLAFSSRNQYLSAAEKEQAAVLYRGLKKAEAAFKSGVRHSSQLIAVVQQEVARVSTVLLEYIELVEPTTLMSLETIEEEGMLAIAARLGSTRLIDNIILRDRQPIIAIDGPAGAGKSTVARQVAAELGLVYLDTGAMYRAITWLVIQKGIALDDECAIAELAHTCKIELTPSQDLKSPVRVWIDDVDVTQEIRTVEVTSKVSAIAAQTAVRQALVNQQQNWGKKGGLVAEGRDIGSHVFPDAEVKIFLTASVSERARRRQQDFKKQGQPEVSLEQLERDIAERDWKDSTRKVSPLQKAADAVELQTDGMNISEVAAQIINYYHQKLSQW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP012036
EMBL· GenBank· DDBJ
ALF51783.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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