A0A0M3RQ25 · A0A0M3RQ25_CANAU

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

137950100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processrespiratory electron transport chain

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      CYB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • CAU_Afghanistan_N2234
    • CAU_Egypt55
    • CAU_Israel50
    • CAU_Israel54
    • CAU_Israel_RKW1326
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis

Accessions

  • Primary accession
    A0A0M3RQ25

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-52Helical
Transmembrane87-107Helical
Transmembrane113-133Helical
Transmembrane140-158Helical
Transmembrane178-200Helical
Transmembrane229-246Helical
Transmembrane288-307Helical
Transmembrane319-340Helical
Transmembrane346-372Helical

Keywords

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-379Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    379
  • Mass (Da)
    42,721
  • Last updated
    2015-12-09 v1
  • Checksum
    64A1166A3D23D693
MTNIRKTHPLAKIVNNSFIDLPAPSNISAWWNFGSLLGVCLILQILTGLFLAMHYTSDTATAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYVFMETWNIGIVLLFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFIFPFIIAALAMVHLLFLHETGSNNPSGITSDSDKIPFHPYYTIKDILGILLLLLVLMSLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILAFIPFLHTSKQRSMMFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFIIIGQVASILYFTILLILMPTISVIENNLLKW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT447713
EMBL· GenBank· DDBJ
ALD09664.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447715
EMBL· GenBank· DDBJ
ALD09666.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447718
EMBL· GenBank· DDBJ
ALD09669.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447719
EMBL· GenBank· DDBJ
ALD09670.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447724
EMBL· GenBank· DDBJ
ALD09675.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447725
EMBL· GenBank· DDBJ
ALD09676.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447726
EMBL· GenBank· DDBJ
ALD09677.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447727
EMBL· GenBank· DDBJ
ALD09678.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447728
EMBL· GenBank· DDBJ
ALD09679.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447731
EMBL· GenBank· DDBJ
ALD09682.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447732
EMBL· GenBank· DDBJ
ALD09683.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447748
EMBL· GenBank· DDBJ
ALD09699.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447749
EMBL· GenBank· DDBJ
ALD09700.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447750
EMBL· GenBank· DDBJ
ALD09701.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447751
EMBL· GenBank· DDBJ
ALD09702.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447752
EMBL· GenBank· DDBJ
ALD09703.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447754
EMBL· GenBank· DDBJ
ALD09705.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447755
EMBL· GenBank· DDBJ
ALD09706.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447756
EMBL· GenBank· DDBJ
ALD09707.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447757
EMBL· GenBank· DDBJ
ALD09708.1
EMBL· GenBank· DDBJ
Genomic DNA
KT447758
EMBL· GenBank· DDBJ
ALD09709.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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