A0A0M3MIT1 · A0A0M3MIT1_9NEOP

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Thysanoptera > Terebrantia > Thripoidea > Thripidae > Thrips

Accessions

  • Primary accession
    A0A0M3MIT1

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-59Helical
Transmembrane132-153Helical
Transmembrane165-192Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-194Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    194
  • Mass (Da)
    21,375
  • Last updated
    2015-12-09 v1
  • Checksum
    7941AB0F26EA9943
ILYFIFGFWSGMMGLSLSMIIRLNLRTMKLFISNDQFYNSIVTAHAFVMIFFTVMPIMIGGFGNWLVPLMLGAPDMAFPRLNNMSFWLLPPSLGLLIMGLYKEGAGTGWTVYPPLSTFYHSGPSVDLTIFSLHLAGISSILGALNFITTIINLKAKNLSAEKISLFVWSVILTAILLLLSLPVLAGAITMLLTD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue194

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KM529304
EMBL· GenBank· DDBJ
AKH51253.1
EMBL· GenBank· DDBJ
Genomic DNA
KM532338
EMBL· GenBank· DDBJ
AKH54285.1
EMBL· GenBank· DDBJ
Genomic DNA
KM536980
EMBL· GenBank· DDBJ
AKH58927.1
EMBL· GenBank· DDBJ
Genomic DNA
KR145988
EMBL· GenBank· DDBJ
ALT31368.1
EMBL· GenBank· DDBJ
Genomic DNA
MG357037
EMBL· GenBank· DDBJ
AYK47124.1
EMBL· GenBank· DDBJ
Genomic DNA
MG357432
EMBL· GenBank· DDBJ
AYK47519.1
EMBL· GenBank· DDBJ
Genomic DNA
MG358200
EMBL· GenBank· DDBJ
AYK48287.1
EMBL· GenBank· DDBJ
Genomic DNA
MG358433
EMBL· GenBank· DDBJ
AYK48520.1
EMBL· GenBank· DDBJ
Genomic DNA
MG358513
EMBL· GenBank· DDBJ
AYK48600.1
EMBL· GenBank· DDBJ
Genomic DNA
MG358806
EMBL· GenBank· DDBJ
AYK48893.1
EMBL· GenBank· DDBJ
Genomic DNA
MG358835
EMBL· GenBank· DDBJ
AYK48922.1
EMBL· GenBank· DDBJ
Genomic DNA
MG358931
EMBL· GenBank· DDBJ
AYK49018.1
EMBL· GenBank· DDBJ
Genomic DNA
MG359256
EMBL· GenBank· DDBJ
AYK49343.1
EMBL· GenBank· DDBJ
Genomic DNA
MG359508
EMBL· GenBank· DDBJ
AYK49595.1
EMBL· GenBank· DDBJ
Genomic DNA
MG359654
EMBL· GenBank· DDBJ
AYK49741.1
EMBL· GenBank· DDBJ
Genomic DNA
MG359941
EMBL· GenBank· DDBJ
AYK50028.1
EMBL· GenBank· DDBJ
Genomic DNA
MG360034
EMBL· GenBank· DDBJ
AYK50121.1
EMBL· GenBank· DDBJ
Genomic DNA
MG360151
EMBL· GenBank· DDBJ
AYK50238.1
EMBL· GenBank· DDBJ
Genomic DNA
MG360235
EMBL· GenBank· DDBJ
AYK50322.1
EMBL· GenBank· DDBJ
Genomic DNA
MG360946
EMBL· GenBank· DDBJ
AYK51033.1
EMBL· GenBank· DDBJ
Genomic DNA
MG361083
EMBL· GenBank· DDBJ
AYK51170.1
EMBL· GenBank· DDBJ
Genomic DNA
MG361308
EMBL· GenBank· DDBJ
AYK51395.1
EMBL· GenBank· DDBJ
Genomic DNA
MG361421
EMBL· GenBank· DDBJ
AYK51508.1
EMBL· GenBank· DDBJ
Genomic DNA
MG361957
EMBL· GenBank· DDBJ
AYK52044.1
EMBL· GenBank· DDBJ
Genomic DNA
MG363087
EMBL· GenBank· DDBJ
AYK53174.1
EMBL· GenBank· DDBJ
Genomic DNA
MG363096
EMBL· GenBank· DDBJ
AYK53183.1
EMBL· GenBank· DDBJ
Genomic DNA
MG363909
EMBL· GenBank· DDBJ
AYK53996.1
EMBL· GenBank· DDBJ
Genomic DNA
MG365299
EMBL· GenBank· DDBJ
AYK55386.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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