A0A0M3LXQ9 · A0A0M3LXQ9_PSEPR
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids216 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respirasome | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Gobionidae > Sarcocheilichthyinae > Pseudorasbora
Accessions
- Primary accessionA0A0M3LXQ9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 42-62 | Helical | ||||
Sequence: FVMIFFMVMPILIGGFGNWLV | ||||||
Transmembrane | 83-107 | Helical | ||||
Sequence: LLPPSFLLLLASSGVEAGAGTGWTV | ||||||
Transmembrane | 127-150 | Helical | ||||
Sequence: FSLHLAGVSSILGAINFITTTINM | ||||||
Transmembrane | 162-189 | Helical | ||||
Sequence: LFVWAVLVTAVLLLLSLPVLAAGITMLL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-216 | Cytochrome oxidase subunit I profile | ||||
Sequence: FGAWAGMVGTALSLLIRAELSQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLTHAGASVDLTIFSLHLAGVSSILGAINFITTTINMKPPAISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWF |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length216
- Mass (Da)23,083
- Last updated2015-12-09 v1
- Checksum55E1EC63E14EDE14
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: F | ||||||
Non-terminal residue | 216 | |||||
Sequence: F |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KM610816 EMBL· GenBank· DDBJ | AJO99323.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610817 EMBL· GenBank· DDBJ | AJO99324.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610821 EMBL· GenBank· DDBJ | AJO99328.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610825 EMBL· GenBank· DDBJ | AJO99332.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610826 EMBL· GenBank· DDBJ | AJO99333.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610827 EMBL· GenBank· DDBJ | AJO99334.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610830 EMBL· GenBank· DDBJ | AJO99337.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610833 EMBL· GenBank· DDBJ | AJO99340.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610835 EMBL· GenBank· DDBJ | AJO99342.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610837 EMBL· GenBank· DDBJ | AJO99344.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610843 EMBL· GenBank· DDBJ | AJO99350.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610846 EMBL· GenBank· DDBJ | AJO99353.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610848 EMBL· GenBank· DDBJ | AJO99355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610850 EMBL· GenBank· DDBJ | AJO99357.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610851 EMBL· GenBank· DDBJ | AJO99358.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610852 EMBL· GenBank· DDBJ | AJO99359.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610853 EMBL· GenBank· DDBJ | AJO99360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610855 EMBL· GenBank· DDBJ | AJO99362.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610859 EMBL· GenBank· DDBJ | AJO99366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610866 EMBL· GenBank· DDBJ | AJO99373.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610867 EMBL· GenBank· DDBJ | AJO99374.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM610868 EMBL· GenBank· DDBJ | AJO99375.1 EMBL· GenBank· DDBJ | Genomic DNA |