A0A0M3LXQ9 · A0A0M3LXQ9_PSEPR

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Gobionidae > Sarcocheilichthyinae > Pseudorasbora

Accessions

  • Primary accession
    A0A0M3LXQ9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane42-62Helical
Transmembrane83-107Helical
Transmembrane127-150Helical
Transmembrane162-189Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-216Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    216
  • Mass (Da)
    23,083
  • Last updated
    2015-12-09 v1
  • Checksum
    55E1EC63E14EDE14
FGAWAGMVGTALSLLIRAELSQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLTHAGASVDLTIFSLHLAGVSSILGAINFITTTINMKPPAISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue216

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KM610816
EMBL· GenBank· DDBJ
AJO99323.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610817
EMBL· GenBank· DDBJ
AJO99324.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610821
EMBL· GenBank· DDBJ
AJO99328.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610825
EMBL· GenBank· DDBJ
AJO99332.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610826
EMBL· GenBank· DDBJ
AJO99333.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610827
EMBL· GenBank· DDBJ
AJO99334.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610830
EMBL· GenBank· DDBJ
AJO99337.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610833
EMBL· GenBank· DDBJ
AJO99340.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610835
EMBL· GenBank· DDBJ
AJO99342.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610837
EMBL· GenBank· DDBJ
AJO99344.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610843
EMBL· GenBank· DDBJ
AJO99350.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610846
EMBL· GenBank· DDBJ
AJO99353.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610848
EMBL· GenBank· DDBJ
AJO99355.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610850
EMBL· GenBank· DDBJ
AJO99357.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610851
EMBL· GenBank· DDBJ
AJO99358.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610852
EMBL· GenBank· DDBJ
AJO99359.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610853
EMBL· GenBank· DDBJ
AJO99360.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610855
EMBL· GenBank· DDBJ
AJO99362.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610859
EMBL· GenBank· DDBJ
AJO99366.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610866
EMBL· GenBank· DDBJ
AJO99373.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610867
EMBL· GenBank· DDBJ
AJO99374.1
EMBL· GenBank· DDBJ
Genomic DNA
KM610868
EMBL· GenBank· DDBJ
AJO99375.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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