A0A0M2UQQ7 · A0A0M2UQQ7_9BACT

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site239pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site273-276pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site276substrate
Binding site313substrate
Binding site317substrate
Active site357Proton donor
Binding site358substrate
Binding site386pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site386substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase
    ; DAPDC

Gene names

    • Name
      lysA
    • ORF names
      BROFUL_02862

Organism names

  • Taxonomic identifier
  • Strain
    • RU1
  • Taxonomic lineage
    Bacteria > Planctomycetota > Candidatus Brocadiia > Candidatus Brocadiales > Candidatus Brocadiaceae > Candidatus Brocadia

Accessions

  • Primary accession
    A0A0M2UQQ7

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue60N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-279Orn/DAP/Arg decarboxylase 2 N-terminal
Domain280-384Orn/DAP/Arg decarboxylase 2 C-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    430
  • Mass (Da)
    47,573
  • Last updated
    2015-11-11 v1
  • Checksum
    2F9172289A7FC3DD
MDAFEYRDKTLFCEKVKIEDIISEVGTPAYIYSKNAILARYHELKAAFGDVDSLICFSVKSNSNLSLCKILAEAGSGFDVVSGGELFRTIKAGGDPSKIVFAGVGKTDGEIRDALANDIFMFNVESLAELEHIDRLARDVGKVAKVALRINPDIDAKTHAKTTTGKKENKFGIDFTEAEGLIKQSSRYPGIELCGLHVHLGSPIYTVDPYVNALRKIIKLIEKCRDAGLDIEYMNIGGGYCISYTGEEVIRPRDYASKILPLVKEMQCNLLMEPGRFITGNSGILITRVTYTKETVHGKKFIICDAAMNDLLRPALYDAFHRIWPVTTGIPMPKVEEPEKAAVKKGTELVDIVGPVCESSDVFASKRALPKVGEGDLLAIFSAGAYGFSMSSQYNSRPRPCEVLVDRDQYRIIRERETYDDLIKGEIIPE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LAQJ01000270
EMBL· GenBank· DDBJ
KKO18428.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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