A0A0M2K7I5 · A0A0M2K7I5_9GAMM

  • Protein
    5'/3'-nucleotidase SurE
  • Gene
    surE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 1 divalent metal cation per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site8a divalent metal cation (UniProtKB | ChEBI)
Binding site9a divalent metal cation (UniProtKB | ChEBI)
Binding site39a divalent metal cation (UniProtKB | ChEBI)
Binding site92a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3'-nucleotidase activity
Molecular Functionexopolyphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXMP 5'-nucleosidase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5'/3'-nucleotidase SurE
  • EC number
  • Alternative names
    • Exopolyphosphatase
      (EC:3.6.1.11
      ) . EC:3.6.1.11 (UniProtKB | ENZYME | Rhea)
    • Nucleoside monophosphate phosphohydrolase

Gene names

    • Name
      surE
    • ORF names
      AV903_12820
      , SY86_07900

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • BuffGH
    • MDcuke
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Erwinia

Accessions

  • Primary accession
    A0A0M2K7I5

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-181Survival protein SurE-like phosphatase/nucleotidase

Sequence similarities

Belongs to the SurE nucleotidase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    253
  • Mass (Da)
    26,934
  • Last updated
    2015-11-11 v1
  • Checksum
    D6E4ABEF87879821
MRILLSNDDGIHAPGIQILAEALREFAEVQVVAPDRNRSGASNSLTLETPLRTFEYPNGDIAVQMGTPTDCVWLGVNTLMSPKPDVVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGLPALAVSLNGHQHYETAAAVTCSILRALQREPLRTGRILNINVPDLPLAGLKGIRVTRCGSRHPSDQAIPQLDPRGNTLYWIGPPGDKLDAGPDTDFAAIDEGYVSVTALHVDLTAHSAQQVLAGWLARVEVSGEW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP013970
EMBL· GenBank· DDBJ
AXF76714.1
EMBL· GenBank· DDBJ
Genomic DNA
JXNU01000003
EMBL· GenBank· DDBJ
KKF35355.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help