A0A0M2K5I8 · A0A0M2K5I8_9GAMM

  • Protein
    N-acetylmuramic acid 6-phosphate etherase
  • Gene
    murQ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

Miscellaneous

A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.

Catalytic activity

Pathway

Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.
Amino-sugar metabolism; N-acetylmuramate degradation.
Cell wall biogenesis; peptidoglycan recycling.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site83Proton donor
Active site114

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncarbohydrate binding
Molecular Functioncarbon-oxygen lyase activity
Molecular Functionenzyme binding
Molecular Functionenzyme inhibitor activity
Molecular Functionfructose-6-phosphate binding
Biological Process1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
Biological Processamino sugar catabolic process
Biological Processglucose homeostasis
Biological ProcessN-acetylmuramic acid catabolic process
Biological Processpeptidoglycan turnover
Biological Processresponse to fructose

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylmuramic acid 6-phosphate etherase
  • EC number
  • Short names
    MurNAc-6-P etherase
  • Alternative names
    • N-acetylmuramic acid 6-phosphate hydrolase
    • N-acetylmuramic acid 6-phosphate lyase

Gene names

    • Name
      murQ
    • ORF names
      AV903_00745
      , SY86_24875

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • BuffGH
    • MDcuke
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Erwinia

Accessions

  • Primary accession
    A0A0M2K5I8

Proteomes

Subcellular Location

Expression

Induction

Induced by MurNAc 6-phosphate that releases the repressor MurR from the DNA. Repressed by MurR in the absence of MurNAc 6-phosphate.

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain55-218SIS

Sequence similarities

Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    297
  • Mass (Da)
    30,764
  • Last updated
    2015-11-11 v1
  • Checksum
    2983EB6A4565F498
MNLASLVSETRNADTMELDNLSTLEMVTKFNQQDATVAIAVSKTLPDVARAVDAAALSLSEGGRLIYVGAGTSGRLGVLDASECPPTFGVPHGVVVGLIAGGPGAMLKAVEGAEDDPQLGIDDLSALNLTARDMVVGIAASGRTPYVIGALRFAHQLGCRTVALSCNPDSPIAQEADIAISPVVGPEALTGSTRLKSGTAQKLVLNMLSTGAMVKTGKVYQNLMVDMQATNIKLVDRASRMVCEATGCAVADAVAALRQSNYAVKTAILMILSEVTAAQAETLLLKHKGFLRSALRD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP013970
EMBL· GenBank· DDBJ
AXF74964.1
EMBL· GenBank· DDBJ
Genomic DNA
JXNU01000005
EMBL· GenBank· DDBJ
KKF34229.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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