A0A0L8RF23 · A0A0L8RF23_SACEU

Function

function

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Sulfur metabolism; glutathione metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site177L-glutamate (UniProtKB | ChEBI)
Active site470Nucleophile
Binding site488-490L-glutamate (UniProtKB | ChEBI)
Binding site512L-glutamate (UniProtKB | ChEBI)
Binding site540-541L-glutamate (UniProtKB | ChEBI)
Binding site563L-glutamate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentfungal-type vacuole
Cellular Componentplasma membrane
Molecular Functionglutathione hydrolase activity
Molecular Functionleukotriene C4 gamma-glutamyl transferase activity
Biological Processglutathione catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione hydrolase
  • EC number
  • Alternative names
    • Gamma-glutamyltransferase
    • Gamma-glutamyltranspeptidase

Gene names

    • ORF names
      DI49_3804

Organism names

  • Taxonomic identifier
  • Strain
    • FM1318
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces

Accessions

  • Primary accession
    A0A0L8RF23

Proteomes

Subcellular Location

Membrane
; Single-pass membrane protein

PTM/Processing

Keywords

Family & Domains

Sequence similarities

Belongs to the gamma-glutamyltransferase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    660
  • Mass (Da)
    72,881
  • Last updated
    2015-11-11 v1
  • Checksum
    8F42E23B493CCA6A
MPSCSTRNSAAPSIKFIPRVLTLLAICTLVFGLPSKMISFASQESLHRINSLLRSPANREVDKFGTFLNPNKGEDGKDKDHHNIDIDPLLRSPSLTPDHQLLKIGLHGAISSDLEICSNLTINEVLLKFPGSNAADAAVTQALCKGMVNFFNSGIGGGGYVVFSGKSDDDHLSIDFREKAPAGSHKHMFENCSLCSKIGGLAVGVPGELMGLYRLYEERGSGQVGWYDLIEPVAKLGSGGWQIDEVLGASLRLYEDVFLTLKEDWSFVLNSTQNGVLKKGDWIKRPMLANMLMELAHNGSVTPFYDPNHWIAKSMVSTIEKYNGIMNLDDVASYDVHVTKPLSTQIRKGVNYIPDNDMTVLTSSGSSSGAALLSALKIMDNFHNQEGGDYVEENTYQLLESMKWMASARSRLGDYEGETLPKHIKEVLDPEWALKAVESIRSNSLDGKFKTLENWTLYDPAYEINNPHGTAHFSIVDSQGNAVSLTTTVNLLFGSLVHDPKTGVIFNNEMDDFAQFNTSNSFELAPSIYNFPEPGKRPLSSTAPTIVLSELGIPDLVVGASGGSRITTSVLQAIVRTYWYKMPILETVAYPRMHHQLLPDHVEVESFPMVGKSTLRTLKEMGYTMKEVFPKSVVNAIRNVRGEWHAVSDYWRKRGISSVY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JMCK01000012
EMBL· GenBank· DDBJ
KOG97982.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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