A0A0L8RF23 · A0A0L8RF23_SACEU
- ProteinGlutathione hydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids660 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 177 | L-glutamate (UniProtKB | ChEBI) | |||
Active site | 470 | Nucleophile | |||
Binding site | 488-490 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 512 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 540-541 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 563 | L-glutamate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | fungal-type vacuole | |
Cellular Component | plasma membrane | |
Molecular Function | glutathione hydrolase activity | |
Molecular Function | leukotriene C4 gamma-glutamyl transferase activity | |
Biological Process | glutathione catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionA0A0L8RF23
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
PTM/Processing
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length660
- Mass (Da)72,881
- Last updated2015-11-11 v1
- Checksum8F42E23B493CCA6A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JMCK01000012 EMBL· GenBank· DDBJ | KOG97982.1 EMBL· GenBank· DDBJ | Genomic DNA |