A0A0L8I9W8 · A0A0L8I9W8_OCTBM

Function

function

In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants.
Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).

Catalytic activity

  • 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine
    This reaction proceeds in the forward direction.
  • tRNA(Cys) + L-cysteine + ATP = L-cysteinyl-tRNA(Cys) + AMP + diphosphate
    This reaction proceeds in the backward direction.
    EC:6.1.1.16 (UniProtKB | ENZYME | Rhea)
  • S-disulfanyl-L-cysteine + tRNA(Cys) + ATP = (S)-disulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • S-sulfanyl-L-cysteine + tRNA(Cys) + ATP = (S)-sulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphate
    This reaction proceeds in the forward direction.
  • S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine
    This reaction proceeds in the forward direction.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular FunctionATP binding
Molecular Functioncysteine-tRNA ligase activity
Molecular Functionmetal ion binding
Biological Processcysteinyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    cysteine--tRNA ligase
  • EC number
  • Alternative names
    • Cysteinyl-tRNA synthetase

Gene names

    • ORF names
      OCBIM_22028389mg

Organism names

Accessions

  • Primary accession
    A0A0L8I9W8

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain103-394tRNA synthetases class I catalytic

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    601
  • Mass (Da)
    69,407
  • Last updated
    2015-11-11 v1
  • MD5 Checksum
    7C8D3747B95DD4BE583C19E5FE59D5AA
MVWFRIHPRSKVNMYNFLHLELRWLSRCYHTKHHEKLVLRQITTYLSSLTSSLSSKDTRPNGREHLAVVPKYHSTWIQPEGFDTGIKVYNTLTKQKEKLILLRKNIATWYICGPTVYDSAHLGHASTYIQFDIIRRILTKIFGIHVIRVMSITDVDDKIIDRANKLGTEISEVSKKFEYEFFHDMALLNVLPPTYPARVTDHMDSIINCIQTILQKGFAYKTPGGSVYFNVEAYPDYGQLRQKQEIFEESTHEGKHSSLDFALWKATKQGPSWESPWGKGRPGWHIECSAMASKIFGSNFDLHSGGEDLIFPHHENELAQSQTYHGCKQWCNYWLHTGHLHIKDQEKMSKSLKNVVLISDLLKTYTANQFRFFCMLTHYRRRIAYHKESIEKASKLLTQIESYLQNSSAYILGQKNCRNISESEILSKLDQLQTSVGEALCDDFDLPRTIASIISFVQFMNNELTPTQDPSSSSRSTVAVAVASMYVSELLQSFGINFGKQTQETESSSDLQLSQVINSTVKYRNKIRQFVLSPHEDISFGKDYEDLNKKEKKKLKFQALQPLISSSDDIRKEFAAMDIQIIDYQNDSSWKIVTTKKKKEN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KQ416257
EMBL· GenBank· DDBJ
KOF97814.1
EMBL· GenBank· DDBJ
Genomic DNA
KQ416257
EMBL· GenBank· DDBJ
KOF97815.1
EMBL· GenBank· DDBJ
Genomic DNA
KQ416257
EMBL· GenBank· DDBJ
KOF97816.1
EMBL· GenBank· DDBJ
Genomic DNA
KQ416257
EMBL· GenBank· DDBJ
KOF97817.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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