A0A0L8I9W8 · A0A0L8I9W8_OCTBM
- Proteincysteine--tRNA ligase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids601 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
In addition to its role as an aminoacyl-tRNA synthetase, has also cysteine persulfide synthase activity. Produces reactive persulfide species such as cysteine persulfide (CysSSH) from substrate cysteine and mediate direct incorporation of CysSSH into proteins during translations, resulting in protein persulfides and polysulfides. CysSSHs behave as potent antioxidants and cellular protectants.
Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
Catalytic activity
- 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanineThis reaction proceeds in the forward direction.
- S-disulfanyl-L-cysteine + tRNA(Cys) + ATP = (S)-disulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphateThis reaction proceeds in the forward direction.
- S-sulfanyl-L-cysteine + tRNA(Cys) + ATP = (S)-sulfanyl-L-cysteinyl-tRNA(Cys) + AMP + diphosphateThis reaction proceeds in the forward direction.
- S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanineThis reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-tRNA ligase activity | |
Molecular Function | metal ion binding | |
Biological Process | cysteinyl-tRNA aminoacylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namecysteine--tRNA ligase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Cephalopoda > Coleoidea > Octopodiformes > Octopoda > Incirrata > Octopodidae > Octopus
Accessions
- Primary accessionA0A0L8I9W8
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 103-394 | tRNA synthetases class I catalytic | |||
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length601
- Mass (Da)69,407
- Last updated2015-11-11 v1
- MD5 Checksum7C8D3747B95DD4BE583C19E5FE59D5AA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KQ416257 EMBL· GenBank· DDBJ | KOF97814.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KQ416257 EMBL· GenBank· DDBJ | KOF97815.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KQ416257 EMBL· GenBank· DDBJ | KOF97816.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KQ416257 EMBL· GenBank· DDBJ | KOF97817.1 EMBL· GenBank· DDBJ | Genomic DNA |