A0A0L8G6H1 · A0A0L8G6H1_OCTBM
- ProteinKatanin p60 ATPase-containing subunit A1
- GeneKATNA1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids476 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
Catalytic activity
Activity regulation
ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | cytoplasm | |
Cellular Component | microtubule | |
Cellular Component | spindle pole | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | isomerase activity | |
Molecular Function | microtubule binding | |
Molecular Function | microtubule severing ATPase activity | |
Biological Process | cell division | |
Biological Process | microtubule severing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKatanin p60 ATPase-containing subunit A1
- EC number
- Short namesKatanin p60 subunit A1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Cephalopoda > Coleoidea > Octopodiformes > Octopoda > Incirrata > Octopodidae > Octopus
Accessions
- Primary accessionA0A0L8G6H1
Subcellular Location
UniProt Annotation
GO Annotation
Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.
Keywords
- Cellular component
Interaction
Subunit
Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 97-171 | Disordered | ||||
Sequence: DQESWPLPTPVEHKPSPNLWVPHRAQPKKPEPKKSNPRVPLARQKPSSADKNKDRGGRERSKRKEEDEKKFDPPG | ||||||
Compositional bias | 143-171 | Basic and acidic residues | ||||
Sequence: SSADKNKDRGGRERSKRKEEDEKKFDPPG | ||||||
Domain | 226-368 | AAA+ ATPase | ||||
Sequence: PWKGVLMVGPPGTGKTMLARALATECGTTFFNVSSSSLTSKWRGESERLVKLLFEMARFYAPSTIFIDEIDSICSRRGGDEHESSRRVKSELLVEMDGVSTSTYDDDSEGKIVMVLAATNFPWDLDEALRRRLEKRIYIPLPD |
Sequence similarities
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length476
- Mass (Da)54,311
- Last updated2015-11-11 v1
- ChecksumBD557861B51C4A0C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 143-171 | Basic and acidic residues | ||||
Sequence: SSADKNKDRGGRERSKRKEEDEKKFDPPG |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KQ423808 EMBL· GenBank· DDBJ | KOF72160.1 EMBL· GenBank· DDBJ | Genomic DNA |