A0A0L8G6H1 · A0A0L8G6H1_OCTBM

Function

function

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Catalytic activity

  • n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
    EC:5.6.1.1 (UniProtKB | ENZYME | Rhea)

Activity regulation

ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.

Features

Showing features for binding site.

147650100150200250300350400450
TypeIDPosition(s)Description
Binding site234-241ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Cellular Componentspindle pole
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionisomerase activity
Molecular Functionmicrotubule binding
Molecular Functionmicrotubule severing ATPase activity
Biological Processcell division
Biological Processmicrotubule severing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Katanin p60 ATPase-containing subunit A1
  • EC number
  • Short names
    Katanin p60 subunit A1
  • Alternative names
    • p60 katanin

Gene names

    • Name
      KATNA1
    • ORF names
      OCBIM_22039951mg

Organism names

Accessions

  • Primary accession
    A0A0L8G6H1

Subcellular Location

Cytoplasm
Note: Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.

Keywords

Interaction

Subunit

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region97-171Disordered
Compositional bias143-171Basic and acidic residues
Domain226-368AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    476
  • Mass (Da)
    54,311
  • Last updated
    2015-11-11 v1
  • Checksum
    BD557861B51C4A0C
MSEAMLTDIAETAKNAREYAITGNYDTSLVYYRGLLLKVQKLLVSTKDRTKQSTWSRAKTYFTKEYDAVKNILTILTGMQKCNAGSYLFVHEEPTRDQESWPLPTPVEHKPSPNLWVPHRAQPKKPEPKKSNPRVPLARQKPSSADKNKDRGGRERSKRKEEDEKKFDPPGVDKELVANLERDIVQRNPNVHWEDIADLVEAKKLLKEAVVLPLIRPDIFKGIRRPWKGVLMVGPPGTGKTMLARALATECGTTFFNVSSSSLTSKWRGESERLVKLLFEMARFYAPSTIFIDEIDSICSRRGGDEHESSRRVKSELLVEMDGVSTSTYDDDSEGKIVMVLAATNFPWDLDEALRRRLEKRIYIPLPDANGREELLKINLREVEIEKDVDLKVIAERLNGYSGADITNLCRDAAMMSFRRRIAGLTSEQIRNIPKEELELPSSMADFEEAIKKVSKSVSQDDLKRYENWMKEYGSV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias143-171Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KQ423808
EMBL· GenBank· DDBJ
KOF72160.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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