A0A0L8FL84 · A0A0L8FL84_OCTBM

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site260Nucleophile
Active site344
Active site346

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functiondihydroorotase activity
Molecular Functionmetal ion binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processcitrulline biosynthetic process
Biological Processglutamine metabolic process
Biological ProcessUTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Submitted names
    • Uncharacterized protein

Gene names

    • ORF names
      OCBIM_22015397mg

Organism names

Accessions

  • Primary accession
    A0A0L8FL84

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain521-713ATP-grasp
Domain1057-1248ATP-grasp
Domain1313-1470MGS-like

Sequence similarities

In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,256
  • Mass (Da)
    250,033
  • Last updated
    2015-11-11 v1
  • Checksum
    384B6111E6A7D62D
MGSIKMPKKATLFLEDGSRFSGQLFGHPVSVAGEVVFQTGMVGYPESLTDPSYKSQILILTYPLIGNYGIPSQKKDKNGLPLWFESAKIHASALIIGALSDDYSHWNAVRSLSDWLAEESIPAICGIDTRALTKRIRDKGTMLGKVILEGTDPSILAFSDPNREHLVEQVSIKEPVVYNQEGNLKIVAIDCGMKYNQVRCLTQRGVSVKVVPWNYPVKPDEYDGLFISNGPGDPMLCTDTINNLKQLIDDPRCKPIFGICLGHQLLSLAIGAKTYKMKYGNRGHNQPCTHLDTSRCFITTQNHGFAVDAKTLPDGWSPLFINENDQTNEGVIHHTKPFFSVQFHPEHTAGPEDLEFLFDVFVEQVRAVKAGHAKFSIRESIRQKLNYVCNPMPPCRKVLLLGSGGLSIGQAGEFDYSGSQAIKALTEEGIQIILINPNIATVQTSKWLADKVYFLPITADYVTDVIKNERPDGVLLTFGGQTALNCGFELTKLGVFEKYGVKVLGTQVHSIERTEDRKIFADNMAEINEQVPPSEAAYTVEAAIEAADRIGYPVMLRAAYALGGLCSGFATNGDELQALANTAFKHTSQVLIDKSLKGWKEVEYEVVRDAYNNCITVCNMENVDPLGIHTGESIVVAPSQTLTNKEYNMLRTTAIKVVRHLGIVGECNIQYAVNPESHEFYIIEVNARLSRSSALASKATGYPLAYVAAKLALGKPLPELRNSVTNSTTACFEPSLDYCVVKIPRWDLSKFSRVSTKIGSSMKSVGEAMAIGRKFEEALQKALRMVDEGVNGFDPYHKEPSEEELQNPTDKRIFVVASALKKGYSIEKLYQLTKIDRWFLNRFKVIVDQYTLLEQFQTRPCDLPKQVLLQAKQLGFCDLQIAKCVSSTELVIRHTREQFGVKPWVKQIDTVAAEWPAETNYLYLTYNSIEHDLPFAEGHIMVLGSGVYRIGSSVEFDWCAVNCISELRAMSHKTIMVNCNPETVSTDYDMCDRLYFDEISFETVMDIYDLENPEGIILSMGGQLPNNIAMSLHRQQARILGTSPEFIDNAENRFKFSRMLDNMGISQPMWRELDDLEEAKKFCDTVGFPCLVRPSYVLSGAAMNVAHTHKDLESYLTQASAVSKEHPVVISKFILEAKEIDVDAVACDGEVVCMAISEHVENAGVHSGDATLMTPPQDINEKTLARIKLICCTVGRALEVTGPFNLQLIAKDNQLKVIECNVRVSRSFPFVSKALDHDFIAMATRAIMGEKLEPVNVLAGCRKVALKVPVFSFSRLRGADVLLGVEMASTGEVAGFGEDRYEAYLKAQLSSGFKIPHRNILISIGSFKHKNELLPSVKTLEEIGYNLFASMGTADFYTEHGVKIKAVDWPYENISENGNGNGVEQRTIADYLAKNMFDLVINLPMRNGGTYRASSFVTQGYKTRRMAIDYSVPLITDVKCTKLLVEALRRLREAPPLKIQYDCMTSRRVVRLPGLIDVHVHVREPGAIQKEDWQTATKAALAGGITMILAMPNTQPAVVDQASFALVQKIAKNAAHCDYGINVGASKDNAQTLVQIGAKAGALKMYLNETYTTLKLDSMADWQKHFENWPANLPLCVHAEGTTTAAVILLAELYQRPVHICHVARKEEIMIIKAAKDVGIPVTCEVAPHHLFLSTDDNKVIGEGRCQVRPSLQTAEDQQALWDHMDVVDCFATDHAPHTLEEKDSEKPPPGFPGLETMLPLLLTAVSEGRLTLEDIILRLHSNPKKIFNLPDQLDTYVEVDMDTFYTIPKQPKQSKCKWTPFAGHRVCGAVRRVVIRGEIAFIDGEVLVQPGFGIDVRSLPQPTSSTQLPISEQLTVQIPTMASLSQPPSEPTSPRKMIPSTTLTAASNQPGPFAFPGRGLPKMSQPTHESHQAAYHHDHLEPTSKELGTEPILREYTGSALPCSDLLAKKDQAVAQPAPYLFTPPVHSGLTGHHILNVQSFHKEQLHQLFNQAHNYRMSVQRDRALDHILKGKVMASMFYEVSTRTSCSFGAAMQRLGGSVITFNEATSSVQKGETLEDTVQTMSGYADVIVLRHPKPGAVMKAAQHCRKPVINAGDGTGEHPTQALLDVFTIREEIGTVNGLTITMVGDLRNGRTVHSLARILTLYRVNLCYISPPTLEMPTDVQEYVRSKGITQTAFNSLTDIIADTDVLYITRIQKERFSSLVDYEKACGQIILTPELMTKAKKKMVVMHPLPRVNEISTALDSDPRAAYFRQAENGMFVRMALLAMTLGRA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KQ429320
EMBL· GenBank· DDBJ
KOF65486.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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