A0A0L8FL84 · A0A0L8FL84_OCTBM
- ProteinUncharacterized protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2256 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- (S)-dihydroorotate + H2O = H+ + N-carbamoyl-L-aspartate
Cofactor
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 260 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 344 | |||||
Sequence: H | ||||||
Active site | 346 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | amino acid binding | |
Molecular Function | aspartate carbamoyltransferase activity | |
Molecular Function | ATP binding | |
Molecular Function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | |
Molecular Function | dihydroorotase activity | |
Molecular Function | metal ion binding | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process | |
Biological Process | citrulline biosynthetic process | |
Biological Process | glutamine metabolic process | |
Biological Process | UTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Cephalopoda > Coleoidea > Octopodiformes > Octopoda > Incirrata > Octopodidae > Octopus
Accessions
- Primary accessionA0A0L8FL84
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 521-713 | ATP-grasp | ||||
Sequence: ADNMAEINEQVPPSEAAYTVEAAIEAADRIGYPVMLRAAYALGGLCSGFATNGDELQALANTAFKHTSQVLIDKSLKGWKEVEYEVVRDAYNNCITVCNMENVDPLGIHTGESIVVAPSQTLTNKEYNMLRTTAIKVVRHLGIVGECNIQYAVNPESHEFYIIEVNARLSRSSALASKATGYPLAYVAAKLAL | ||||||
Domain | 1057-1248 | ATP-grasp | ||||
Sequence: SRMLDNMGISQPMWRELDDLEEAKKFCDTVGFPCLVRPSYVLSGAAMNVAHTHKDLESYLTQASAVSKEHPVVISKFILEAKEIDVDAVACDGEVVCMAISEHVENAGVHSGDATLMTPPQDINEKTLARIKLICCTVGRALEVTGPFNLQLIAKDNQLKVIECNVRVSRSFPFVSKALDHDFIAMATRAIM | ||||||
Domain | 1313-1470 | MGS-like | ||||
Sequence: FKIPHRNILISIGSFKHKNELLPSVKTLEEIGYNLFASMGTADFYTEHGVKIKAVDWPYENISENGNGNGVEQRTIADYLAKNMFDLVINLPMRNGGTYRASSFVTQGYKTRRMAIDYSVPLITDVKCTKLLVEALRRLREAPPLKIQYDCMTSRRVV |
Sequence similarities
In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,256
- Mass (Da)250,033
- Last updated2015-11-11 v1
- Checksum384B6111E6A7D62D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KQ429320 EMBL· GenBank· DDBJ | KOF65486.1 EMBL· GenBank· DDBJ | Genomic DNA |