A0A0L7K662 · A0A0L7K662_PLAFX

Function

function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Functionmetal ion binding
Biological ProcessDNA topological change
Biological Processresolution of meiotic recombination intermediates
Biological Processsister chromatid segregation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 2
  • EC number

Gene names

    • ORF names
      PFHG_00531

Organism names

  • Taxonomic identifier
  • Strain
    • HB3
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)

Accessions

  • Primary accession
    A0A0L7K662

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, domain, coiled coil, compositional bias.

TypeIDPosition(s)Description
Region260-317Disordered
Domain493-608Toprim
Coiled coil1153-1180
Region1213-1247Disordered
Compositional bias1262-1276Polar residues
Region1262-1360Disordered
Compositional bias1289-1333Polar residues
Compositional bias1334-1348Basic and acidic residues
Compositional bias1403-1423Basic and acidic residues
Region1403-1472Disordered
Compositional bias1434-1451Basic and acidic residues
Compositional bias1452-1472Polar residues

Sequence similarities

Belongs to the type II topoisomerase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,472
  • Mass (Da)
    169,217
  • Last updated
    2015-11-11 v1
  • Checksum
    315716F39B59916A
MAKNKTIEERYQKKSQIEHILLRPDTYIGSVEMHTQLLWVWNKEKNRMVQKNITYVPGLYKIFDEIIVNAADVKAREKEKSENPMTCIKIEINKENKRISVYNDGEGIPVDIHKEMNIYVPHMIFGELLTSDNYDDAEDRITGGRNGFGAKLTNIFSKEFIVQCGDSSRKKEFKMTWSDNMSKFSEPHIKNYNGKDYVKVTFKPDLNKFGMTEMDDDIESLLFKRVYDLAGTCSVRVYLNGQRLAVKDFKSYVDLYLKDNSNDNKNNKGQNDNNNNNNNNNDENANQNNDNLDVSLSNEPADGTPTKNNNNNNNNNDEDEIVKIHEKQHRWEIVVSKSDGSQFQQVSFVNSICTTKGGSHVNYIVEQLLSSLSKKANAKNKGGMEIKSGHIRNHLWVFVNCLIVNPTFDSQTKETLTTKPVKFGSKCILSDKTINNVLKSPILSNILLWAQAKAQVELKKKMKAGSSKARERIIGIPKLEDANDAGSKYSQECTLILTEGDSAKTSCLAGLSIVGRDKYGVFPLKGKLLNVRDASFKQLMDNKEIQNIFRIMGLDITDKNKDDIKGLRYGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKHKGFLSEFVTPIVKVQKGSQEYSFFTIAEYEQWKENTNLLGWKIKYYKGLGTSTDREFKQYFSDIKNHKIMFLWTGDRDGDSIDMAFSKKRIEDRKLWLQNFILGSYVDHKEKDLSYYDFVNKELIYYSRYDTERSIPNIMDGWKPGQRKVLYGCFKRNLRNECKVAQLVGYIAEHSAYHHGESSLQQTIINMAQTFVGSNNINFLEPCGQFGSRKEGGKDASAARYIFTKLASSTRSIFNEYDDPILKYLNEEGQKIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMVPWYKDFKGRIESNGKTGYETIGIINKIDNDTLEITELPIKKWTQDYKEFLEELLTDEKHQLILDYIDNSSHEDICFTIKMDPAKLQKAEEEGLEKVFKLKSTLTTTNMTLFDPNLKLQRYSTELDILKEFCYQRLKAYENRKSYLISKLEKEKRIISNKTKFILAIVNNELIVNKKKKKVLVEELYRKGYDPYKDINKIKKEEIFEQELLDAADNPEDNEEIIAGITVKDYDYLLSMPIFSLTLEKVEDLLTQLKEKERELEILRNITVETMWLKDIEKVEEAIEFQRNVELSNREESNKFKVARKQGPSSMKKKKKKKKLSSDEESEGGDISDSSEFLVNTLNIKKNTNKKTTTSSNNVNNSKKRLRKADDLNSNELDNTLSVSKTFDDNNNLTDNTPLINRLNDENNEFSSNNVDNKSTNKNSRKKKPKIADSTNDNNSELNSSIQINDNVNDDINITISPNKTINVNEFSSIKNKLLELENKKKPRLTLSEKVKMKNNDKKDTPNKGSAGKRTSSKKLKGTLIGDDSKSRQDSNFDSDASSKNNESYGDSDSSYNI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1262-1276Polar residues
Compositional bias1289-1333Polar residues
Compositional bias1334-1348Basic and acidic residues
Compositional bias1403-1423Basic and acidic residues
Compositional bias1434-1451Basic and acidic residues
Compositional bias1452-1472Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH671924
EMBL· GenBank· DDBJ
KOB58782.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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