A0A0L0TBY1 · A0A0L0TBY1_ALLM3

Function

function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 3/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site45O2 (UniProtKB | ChEBI)
Binding site49Fe cation (UniProtKB | ChEBI); catalytic
Binding site55Fe cation (UniProtKB | ChEBI); catalytic
Binding site55substrate
Binding site94Fe cation (UniProtKB | ChEBI); catalytic
Binding site98substrate
Binding site108substrate
Binding site123a divalent metal cation (UniProtKB | ChEBI)
Binding site126a divalent metal cation (UniProtKB | ChEBI)
Binding site160a divalent metal cation (UniProtKB | ChEBI)
Binding site163a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-hydroxyanthranilate 3,4-dioxygenase activity
Molecular Functionferrous iron binding
Biological Process'de novo' NAD biosynthetic process from tryptophan
Biological Processanthranilate metabolic process
Biological Processquinolinate biosynthetic process
Biological Processtryptophan catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-hydroxyanthranilate 3,4-dioxygenase
  • EC number
  • Alternative names
    • 3-hydroxyanthranilate oxygenase
      (3-HAO
      )
    • 3-hydroxyanthranilic acid dioxygenase
      (HAD
      )
    • Biosynthesis of nicotinic acid protein 1

Gene names

    • Name
      BNA1
    • ORF names
      AMAG_16709

Organism names

Accessions

  • Primary accession
    A0A0L0TBY1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the 3-HAO family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    170
  • Mass (Da)
    19,391
  • Last updated
    2015-11-11 v1
  • Checksum
    703208BDAC40B403
MLPNPLNLPRWLEENKHLLAPPVNNYCVYRGNDFIVMLVGGPNKRTDYHINPTEEWFFQVKGDMLLKVVESDGSFRDVVIKEGDMYLLPPDTPHNPVRFADTIGIVIERPRPAGKNDALRWYCSNCKAIVHEDSFYCVDLGTQLKPVIEQYAQTPALRTCKKCGTVNEAK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG745378
EMBL· GenBank· DDBJ
KNE72226.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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