A0A0L0STC5 · A0A0L0STC5_ALLM3
- ProteinDimethyladenosine transferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids531 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.
Catalytic activity
- adenosine1779/adenosine1780 in 18S rRNA + 4 S-adenosyl-L-methionine = 4 H+ + N6-dimethyladenosine1779/N6-dimethyladenosine1780 in 18S rRNA + 4 S-adenosyl-L-homocysteine
RHEA-COMP:10234 CHEBI:74411 Position: 1779CHEBI:74411 Position: 1780+ 4 CHEBI:59789 = 4 CHEBI:15378 + RHEA-COMP:10236 CHEBI:74493 Position: 1779CHEBI:74493 Position: 1780+ 4 CHEBI:57856
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 191 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 193 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 224 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 246 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 272 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 304 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: N |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | COPII vesicle coat | |
Cellular Component | endoplasmic reticulum exit site | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Molecular Function | 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | RNA binding | |
Biological Process | endoplasmic reticulum to Golgi vesicle-mediated transport | |
Biological Process | intracellular protein transport | |
Biological Process | membrane organization | |
Biological Process | positive regulation of protein exit from endoplasmic reticulum | |
Biological Process | regulation of COPII vesicle coating | |
Biological Process | vesicle organization |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDimethyladenosine transferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Blastocladiomycota > Blastocladiomycetes > Blastocladiales > Blastocladiaceae > Allomyces
Accessions
- Primary accessionA0A0L0STC5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Golgi apparatus membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MFIINWFWSVLASLGLVNKNA | ||||||
Chain | PRO_5005548292 | 22-531 | Dimethyladenosine transferase | |||
Sequence: KILFLGLDNAGKTTLLHMMKNDRLATLSPTLHPTKEELAIGGIKLTTFDLGGHVQARRIWKDYFPEVDAIVFIVDAADRKRIPEAKAELDGLLQMEELSRVPFLVLGNKIDVPGALSEDELRYYLGLHQTTGKGNASLTQGVRPIEVFMCSIVLKQGTYGLVAKQNLSQNFILDQRITDRIVDRVQPARRPTDLSDALVIEVGPGPGLLTRSLIKARGNRIIGIEKDSRFLPLLNQLTDATDGGFRVLHGDALAVSGTDILTFASTHFPTWSATTDPIHVVGNLPFNIATPLLFQLLRGTADRTGLFAREGGVATPTDMTLMFQKEVADRLTAPPGTAARSRVSVMAQVFTDVDLSMDVPRTAFVPKPNVDAAVVHLVPRAHLPREAAEVTAKTGRAFFDVLEDTARRAFAQRRKTVKNSLGSFYTAECVEDMLHAAAIDPAVRAQDLTTDEFCRLAAASVAFPTLHERAAKRAGRDVRAAKSRAQAAAAAQEEVATESAPPTGAEQERS |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 198-402 | Ribosomal RNA adenine methylase transferase N-terminal | ||||
Sequence: ITDRIVDRVQPARRPTDLSDALVIEVGPGPGLLTRSLIKARGNRIIGIEKDSRFLPLLNQLTDATDGGFRVLHGDALAVSGTDILTFASTHFPTWSATTDPIHVVGNLPFNIATPLLFQLLRGTADRTGLFAREGGVATPTDMTLMFQKEVADRLTAPPGTAARSRVSVMAQVFTDVDLSMDVPRTAFVPKPNVDAAVVHLVPRA | ||||||
Region | 498-531 | Disordered | ||||
Sequence: DVRAAKSRAQAAAAAQEEVATESAPPTGAEQERS |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
Belongs to the small GTPase superfamily. SAR1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length531
- Mass (Da)57,858
- Last updated2015-11-11 v1
- Checksum992171DAF375CCA8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GG745348 EMBL· GenBank· DDBJ | KNE65756.1 EMBL· GenBank· DDBJ | Genomic DNA |