A0A0L0STC5 · A0A0L0STC5_ALLM3

Function

function

Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.

Catalytic activity

Features

Showing features for binding site.

153150100150200250300350400450500
TypeIDPosition(s)Description
Binding site191S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site193S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site224S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site246S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site272S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site304S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCOPII vesicle coat
Cellular Componentendoplasmic reticulum exit site
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Molecular Function18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular FunctionRNA binding
Biological Processendoplasmic reticulum to Golgi vesicle-mediated transport
Biological Processintracellular protein transport
Biological Processmembrane organization
Biological Processpositive regulation of protein exit from endoplasmic reticulum
Biological Processregulation of COPII vesicle coating
Biological Processvesicle organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dimethyladenosine transferase
  • EC number
  • Alternative names
    • 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase
    • 18S rRNA dimethylase
    • Mitochondrial transcription factor 1
    • S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
    • small COPII Coat GTPase SAR1

Gene names

    • ORF names
      AMAG_19206

Organism names

Accessions

  • Primary accession
    A0A0L0STC5

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasmic vesicle, COPII-coated vesicle membrane
; Peripheral membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Golgi apparatus membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_500554829222-531Dimethyladenosine transferase

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain198-402Ribosomal RNA adenine methylase transferase N-terminal
Region498-531Disordered

Sequence similarities

Belongs to the small GTPase superfamily. SAR1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    531
  • Mass (Da)
    57,858
  • Last updated
    2015-11-11 v1
  • Checksum
    992171DAF375CCA8
MFIINWFWSVLASLGLVNKNAKILFLGLDNAGKTTLLHMMKNDRLATLSPTLHPTKEELAIGGIKLTTFDLGGHVQARRIWKDYFPEVDAIVFIVDAADRKRIPEAKAELDGLLQMEELSRVPFLVLGNKIDVPGALSEDELRYYLGLHQTTGKGNASLTQGVRPIEVFMCSIVLKQGTYGLVAKQNLSQNFILDQRITDRIVDRVQPARRPTDLSDALVIEVGPGPGLLTRSLIKARGNRIIGIEKDSRFLPLLNQLTDATDGGFRVLHGDALAVSGTDILTFASTHFPTWSATTDPIHVVGNLPFNIATPLLFQLLRGTADRTGLFAREGGVATPTDMTLMFQKEVADRLTAPPGTAARSRVSVMAQVFTDVDLSMDVPRTAFVPKPNVDAAVVHLVPRAHLPREAAEVTAKTGRAFFDVLEDTARRAFAQRRKTVKNSLGSFYTAECVEDMLHAAAIDPAVRAQDLTTDEFCRLAAASVAFPTLHERAAKRAGRDVRAAKSRAQAAAAAQEEVATESAPPTGAEQERS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG745348
EMBL· GenBank· DDBJ
KNE65756.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp