A0A0L0RZD9 · A0A0L0RZD9_ALLM3
- ProteinVery-long-chain 3-oxoacyl-CoA reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids343 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Catalytic activity
- a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 207 | substrate | ||||
Sequence: S | ||||||
Active site | 220 | Proton acceptor | ||||
Sequence: Y |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | ketoreductase activity | |
Molecular Function | very-long-chain 3-oxoacyl-CoA reductase activity | |
Biological Process | fatty acid elongation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVery-long-chain 3-oxoacyl-CoA reductase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Fungi incertae sedis > Blastocladiomycota > Blastocladiomycetes > Blastocladiales > Blastocladiaceae > Allomyces
Accessions
- Primary accessionA0A0L0RZD9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass membrane protein
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length343
- Mass (Da)36,886
- Last updated2015-11-11 v1
- Checksum133A7AB04962194D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GG745329 EMBL· GenBank· DDBJ | KNE55693.1 EMBL· GenBank· DDBJ | Genomic DNA |