A0A0L0JTI1 · A0A0L0JTI1_9ACTN

Function

function

Catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pantetheine 4'-phosphate (UniProtKB | Rhea| CHEBI:47942 )

Note: Binds 1 phosphopantetheine covalently.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site307AMP (UniProtKB | ChEBI)
Binding site402AMP (UniProtKB | ChEBI)
Binding site423-424AMP (UniProtKB | ChEBI)
Binding site428AMP (UniProtKB | ChEBI)
Binding site501AMP (UniProtKB | ChEBI)
Binding site513-516AMP (UniProtKB | ChEBI)
Binding site522AMP (UniProtKB | ChEBI)
Binding site615AMP (UniProtKB | ChEBI)
Binding site784-787NADP+ (UniProtKB | ChEBI)
Binding site811NADP+ (UniProtKB | ChEBI)
Binding site821NADP+ (UniProtKB | ChEBI)
Binding site877-879NADP+ (UniProtKB | ChEBI)
Binding site917NADP+ (UniProtKB | ChEBI)
Binding site948NADP+ (UniProtKB | ChEBI)
Binding site952NADP+ (UniProtKB | ChEBI)
Binding site975NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Molecular Functionphosphopantetheine binding
Biological Processantibiotic biosynthetic process
Biological Processlipid metabolic process
Biological Processsmall molecule metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carboxylic acid reductase
  • EC number
  • Short names
    CAR
  • Alternative names
    • ATP/NADPH-dependent carboxylic acid reductase

Gene names

    • Name
      car
    • ORF names
      IQ63_32555

Organism names

  • Taxonomic identifier
  • Strain
    • NCPPB 4445
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A0L0JTI1

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue684O-(pantetheine 4'-phosphoryl)serine

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain638-725Carrier

Domain

The N-terminal domain likely catalyzes substrate activation by formation of an initial acyl-AMP intermediate, the central region contains the phosphopantetheine attachment site, and the C-terminal domain catalyzes the reduction by NADPH of the intermediate thioester formed from the attack of the phosphopantetheine thiol at the carbonyl carbon of acyl-AMP.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,160
  • Mass (Da)
    125,368
  • Last updated
    2015-11-11 v1
  • Checksum
    0A62461DD6A34D41
MTVMPAKPPADVSPLSRAARLVAELSAHDPQYRAAMPLPAVREAVREAARDQVLSRTVATVMAGYADRPALARRATEPVTDPVSGRTSLRRLPEFTTVTYGELWARAGAVSAEWAADTRLPLAPGDFVALYGFTSGDYVTVDLACLRHGAVSVPLQSGAPVAGLAPILAETGPKVLAVSLELLDRAVELALSADTSPRLVVFDFHAGDDAQREAFEAASARLTAAGHAAPLPLEEVIERGRALPPAPLFVPGPDEDPVRLLIYTSGSTGTPKGAIQTERMLHRAWAGAVPIPDDVASIVVNYLPLSHVAGRSSLVETLRRGGISYFTAHSDLSDLFEDIALARPTALLFVPRVCDLLFQEYQAELARRAGEFADGEALDAAVKADLRERFVGGRLIQALYGSAPLSAELREFMRTCLDLPVLDGYGSTETGSVLLNTRVQRPPVTDIKLVDVPELGYFATDSPYPRGELVLKSATLTPGYYRRPEVTAAAFDADGFYRTGDIMAEVGPDQYVYVDRRNNVVKLAQGEFVALSRLEGVYVTHPLIRQIYVYGNSERAHLLAVIVPTRENLTHEDLSAALQQAARDAELNSYEIPRAFLVETEPFSLANGLLSDTRKNLPPRLKARYGERLEALYEELARDQEDAVRVLRDEGAGRPVSETVERAARALLGSSAADARFTDLGGDSLSALSFSTLLAEIFGVEVPVGTVLSPANDLRALAAHIEARLASGVSRPTFASVHGVGSTVVRAGDLTLEKFIDAGTLAEAAQLPAPGSETPRTVLLTGANGYLGRFMCLDWLERLADSGGRLVCVVRGKDDADARARLDAAFDSGDPELLRRYRELAAGRLDVLAGDIGAERLGLAGETWRRLAEDVDLVAHPAALVNHVLPYEQLFGPNVVGTAELIRLALTARVKPFVYVSTTAISTTLDETSDIRESIPERALTDAYAAGYGTSKWAGEVLLREAHARFGLPVAVFRSDLILAHPHHTGQLNPADVLTRLLFSILSTGLAPTSFYSEEGRAHFDGLPVDFTAEAINTLGAQPTSTHRTYNAVNPHDDGVSLDTFITWLEEAGHPLRRLPHTTWSPRLETALRSLPEHRRPHTLLPLLHAFATPQPPTPTSPVPATHFHEAVREAGIGPDKDIPHITRNLITKYATDLRQLGLW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JPPY01000183
EMBL· GenBank· DDBJ
KND28858.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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