A0A0L0GP63 · A0A0L0GP63_9ENTR
- ProteinATP-dependent zinc metalloprotease FtsH
- GenehflB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids644 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 192-199 | ATP (UniProtKB | ChEBI) | |||
Binding site | 414 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 415 | ||||
Binding site | 418 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 492 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protein catabolic process | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent zinc metalloprotease FtsH
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Trabulsiella
Accessions
- Primary accessionA0A0L0GP63
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 98-119 | Helical | |||
Keywords
- Cellular component
Interaction
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 184-323 | AAA+ ATPase | |||
Region | 600-644 | Disordered | |||
Sequence similarities
Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length644
- Mass (Da)70,909
- Last updated2015-11-11 v1
- Checksum1518A293D02D0448
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JNGI01000037 EMBL· GenBank· DDBJ | KNC93884.1 EMBL· GenBank· DDBJ | Genomic DNA |