A0A0L0CIZ3 · A0A0L0CIZ3_LUCCU
- ProteinE3 ubiquitin-protein ligase parkin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids480 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 447 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi apparatus | |
Cellular Component | mitochondrion | |
Cellular Component | ubiquitin ligase complex | |
Molecular Function | ubiquitin conjugating enzyme binding | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | autophagy of mitochondrion | |
Biological Process | negative regulation of protein phosphorylation | |
Biological Process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
Biological Process | protein polyubiquitination | |
Biological Process | regulation of apoptotic process | |
Biological Process | regulation of cellular response to oxidative stress | |
Biological Process | regulation of mitochondrion organization | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase parkin
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Oestroidea > Calliphoridae > Luciliinae > Lucilia
Accessions
- Primary accessionA0A0L0CIZ3
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 30-99 | Ubiquitin-like | |||
Domain | 253-480 | RING-type | |||
Sequence similarities
Belongs to the RBR family. Parkin subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length480
- Mass (Da)54,050
- Last updated2015-11-11 v1
- Checksum75B5DDD8B4036C7C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JRES01000418 EMBL· GenBank· DDBJ | KNC31434.1 EMBL· GenBank· DDBJ | Genomic DNA |