A0A0L0BRT9 · A0A0L0BRT9_LUCCU
- ProteinSphingomyelin phosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids634 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts sphingomyelin to ceramide.
Catalytic activity
- a sphingomyelin + H2O = an N-acylsphing-4-enine + H+ + phosphocholineThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 220 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 222 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 293 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 293 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 333 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 441 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 475 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 477 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | hydrolase activity, acting on glycosyl bonds | |
Molecular Function | metal ion binding | |
Molecular Function | sphingomyelin phosphodiesterase activity | |
Biological Process | ceramide biosynthetic process | |
Biological Process | sphingomyelin catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSphingomyelin phosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Oestroidea > Calliphoridae > Luciliinae > Lucilia
Accessions
- Primary accessionA0A0L0BRT9
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MLSKLILLALLAVAVRG | ||||||
Chain | PRO_5005535143 | 18-634 | Sphingomyelin phosphodiesterase | |||
Sequence: LNLPGVPVDFEQDDETLSAISQDIANKFSEEYVKFLETGVESSILKQISTQLAKSHTKKDMFTKSIAELHSADQFVMCTTCRSVANVIVETFRAEDGELNGPNAESTTKKMVLELCNRFHIQTPEVCSGLVDLNWPILHYIIMNSLADTRSLCGMLPIRFCKVKQNNFNWSVKVDKGKGLLTAPKSDVPQKTENDLNIVQITDIHFDPDYKVGASAECEEPLCCRLNPLGGVSESAKAGYWSDYRYCDAPLHMVENAFDHIKETHKKIDYIYQTGDIVPHNVWTTSKEGNKAMLTQINDLMIEKFPDVQIFPSVGNHEPHPTNIFGNEDVPAELSMNWLYEHLWSIWQRWLPDEAKETVLKGGYYTVSPKPGFRIISLNNNDCYIYNWWIYLDGSATSQPQLDWLQKTLLAAEKAGEYVHILAHIPSGESDCWTVWAREYNRIIERYSHIIGGIFGGHTHKDEMNLHYSQNGHAMAIYWNGGSLTSYSFKNPNYRTYDIEPVTYQVVDHHTWIFNVTEANELGANGTPRWFKEYQFTEFTNDLSPAGIDALFEKMAAEPDVLLQFWKYKMTSADPLVDAGCNERCLLSTICHLVRTVYDEPGRCNELKAKLKESLNY | ||||||
Disulfide bond | 95↔178 | |||||
Sequence: CTTCRSVANVIVETFRAEDGELNGPNAESTTKKMVLELCNRFHIQTPEVCSGLVDLNWPILHYIIMNSLADTRSLCGMLPIRFC | ||||||
Disulfide bond | 98↔170 | |||||
Sequence: CRSVANVIVETFRAEDGELNGPNAESTTKKMVLELCNRFHIQTPEVCSGLVDLNWPILHYIIMNSLADTRSLC | ||||||
Disulfide bond | 133↔144 | |||||
Sequence: CNRFHIQTPEVC | ||||||
Disulfide bond | 235↔240 | |||||
Sequence: CEEPLC | ||||||
Disulfide bond | 241↔264 | |||||
Sequence: CRLNPLGGVSESAKAGYWSDYRYC | ||||||
Disulfide bond | 400↔449 | |||||
Sequence: CYIYNWWIYLDGSATSQPQLDWLQKTLLAAEKAGEYVHILAHIPSGESDC | ||||||
Disulfide bond | 598↔602 | |||||
Sequence: CNERC | ||||||
Disulfide bond | 608↔621 | |||||
Sequence: CHLVRTVYDEPGRC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 91-182 | Saposin B-type | ||||
Sequence: QFVMCTTCRSVANVIVETFRAEDGELNGPNAESTTKKMVLELCNRFHIQTPEVCSGLVDLNWPILHYIIMNSLADTRSLCGMLPIRFCKVKQ |
Sequence similarities
Belongs to the acid sphingomyelinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length634
- Mass (Da)72,121
- Last updated2015-11-11 v1
- ChecksumBC8C7F4A6A6CE09B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JRES01001458 EMBL· GenBank· DDBJ | KNC22713.1 EMBL· GenBank· DDBJ | Genomic DNA |