A0A0K9PX41 · A0A0K9PX41_ZOSMR

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site13-18ITP (UniProtKB | ChEBI)
Binding site41Mg2+ (UniProtKB | ChEBI)
Binding site53ITP (UniProtKB | ChEBI)
Binding site69Mg2+ (UniProtKB | ChEBI)
Binding site69-70ITP (UniProtKB | ChEBI)
Binding site145-148ITP (UniProtKB | ChEBI)
Binding site168ITP (UniProtKB | ChEBI)
Binding site173-174ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      ZOSMA_15G01340

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Finnish
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Zosteraceae > Zostera

Accessions

  • Primary accession
    A0A0K9PX41

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    194
  • Mass (Da)
    21,487
  • Last updated
    2015-11-11 v1
  • Checksum
    2A5086AF7319940A
MAKNLFRPVTFVTGNAKKLEEVKAILGDSIPFQSIKLDLPELQGEPEDISREKARLASIKVKGPVLVEDTCLCFNALKGLPGPYIKWFLQKIGHEGLNNILNAYEDKSAYAMCVFSLALGPDAEPLTFVGKTQGKIVKSRGPVDFGWDAIFEPDGYNQTYAEMPKDEKNMISHRSKSLALVKSHFADAGYTFQT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LFYR01000620
EMBL· GenBank· DDBJ
KMZ72795.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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